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dc.contributor.authorMochón Benguigui, Sol
dc.contributor.authorCarneiro Barrera, Almudena 
dc.contributor.authorCastillo Garzón, Manuel 
dc.contributor.authorAmaro Gahete, Francisco José
dc.identifier.citationMochón-Benguigui, S.; Carneiro-Barrera, A.; Castillo, M.J.; Amaro-Gahete, F.J. Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study. Antioxidants 2020, 9, 738. [doi:10.3390/antiox9080738]es_ES
dc.descriptionThis work was supported by the Spanish Ministry of Education (grant numbers FPU14/04172, FPU16/01093). This study is part of a Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.es_ES
dc.description.abstractSleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation. However, there are no studies elucidating the relationship between sleep and Klotho. Therefore, this study investigated the association of sleep quantity and quality with the shed form of the α-Klotho gene (S-Klotho plasma levels) in sedentary middle-aged adults. A total of 74 volunteers (52.7% women; aged 53.7 ± 5.1) were recruited for the present study. Objective sleep quality parameters (total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)) were determined using a wrist-worn accelerometer over seven consecutive days, and the subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality). The S-Klotho plasma levels were measured in the ethylenediaminetetraacetic acid plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. Objective sleep parameters were associated with the S-Klotho plasma levels only after including the age, fat mass percentage, and lean mass index as covariates. A direct relationship was observed between the subjective sleep quality (inverse of PSQI scores) and the S-Klotho plasma levels in sedentary middle-aged adults. Improving sleep quantity and quality could be considered an anti-aging therapeutic approach for the prevention, slowing, and even reversal of the physiological decline and degenerative pathologies that are certainly related to the aging process.es_ES
dc.description.sponsorshipSpanish Government FPU14/04172 FPU16/01093es_ES
dc.rightsAtribución 3.0 España*
dc.subjectSuccessful aginges_ES
dc.subjectInflammation es_ES
dc.subjectOxidative stress es_ES
dc.titleIs Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Studyes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España