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dc.contributor.authorChristakoudi, Sofia
dc.contributor.authorSánchez, Maria Jose
dc.date.accessioned2020-10-30T13:00:02Z
dc.date.available2020-10-30T13:00:02Z
dc.date.issued2020-09-03
dc.identifier.citationChristakoudi, S., Tsilidis, K. K., Muller, D. C., Freisling, H., Weiderpass, E., Overvad, K., ... & Zhang, J. (2020). A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort. Scientific reports, 10(1), 1-15. [https://doi.org/10.1038/s41598-020-71302-5]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/63982
dc.description.abstractAbdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI < 18.5 kg/m2) or obese (BMI ≥ 30 kg/m2) categories, while the highest quartile of ABSI separated 18–39% of the individuals within each BMI category, which had 22–55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.es_ES
dc.description.sponsorshipEuropean Commission European Commission Joint Research Centrees_ES
dc.description.sponsorshipInternational Agency for Research on Canceres_ES
dc.description.sponsorshipDanish Cancer Societyes_ES
dc.description.sponsorshipLigue nationale contre le canceres_ES
dc.description.sponsorshipInstitut Gustave Roussyes_ES
dc.description.sponsorshipMutuelle Generale de l'Education Nationale (France)es_ES
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (Inserm)es_ES
dc.description.sponsorshipDeutsche Krebshilfees_ES
dc.description.sponsorshipHelmholtz Associationes_ES
dc.description.sponsorshipFederal Ministry of Education & Research (BMBF)es_ES
dc.description.sponsorshipDeutsche Krebshilfees_ES
dc.description.sponsorshipDeutsches Krebsforschungszentrum (Germany)es_ES
dc.description.sponsorshipFederal Ministry of Education & Research (BMBF)es_ES
dc.description.sponsorshipHellenic Health Foundation (Greece)es_ES
dc.description.sponsorshipAssociazione Italiana per la Ricerca sul Cancro (AIRC)es_ES
dc.description.sponsorshipItalian National Research Counciles_ES
dc.description.sponsorshipDutch Ministry of Public Health, Welfare and Sports (VWS)es_ES
dc.description.sponsorshipNetherlands Cancer Registry (NKR)es_ES
dc.description.sponsorshipLK Research Fundses_ES
dc.description.sponsorshipDutch Prevention Fundses_ES
dc.description.sponsorshipNetherlands Organization for Scientific Research (NWO)es_ES
dc.description.sponsorshipNetherlands Government World Cancer Research Fund International (WCRF)es_ES
dc.description.sponsorshipNetherlands Governmentes_ES
dc.description.sponsorshipEuropean Research Council (Norway) ERC-2009AdG 232997es_ES
dc.description.sponsorshipNordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway)es_ES
dc.description.sponsorshipInstituto de Salud Carlos III PI13/00061 PI13/01162es_ES
dc.description.sponsorshipJunta de Andaluciaes_ES
dc.description.sponsorshipRegional Government of Asturias (Spain)es_ES
dc.description.sponsorshipRegional Government of Basque Country (Spain)es_ES
dc.description.sponsorshipRegional Government of Murcia (Spain)es_ES
dc.description.sponsorshipRegional Government of Navarra (Spain)es_ES
dc.description.sponsorshipCatalan Institute of Oncology (Barcelona) (Spain)es_ES
dc.description.sponsorshipSwedish Cancer Societyes_ES
dc.description.sponsorshipSwedish Research Counciles_ES
dc.description.sponsorshipCounty Council of Skane (Sweden)es_ES
dc.description.sponsorshipCounty Council of Vasterbotten (Sweden)es_ES
dc.description.sponsorshipCancer Research UK 14136 C570/A16491 C8221/A19170es_ES
dc.description.sponsorshipMedical Research Council UK (MRC) 1000143 MR/M012190/1es_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAll-cause mortalityes_ES
dc.subjectAnthropometric measureses_ES
dc.subjectMass indexes_ES
dc.subjectOverweightes_ES
dc.subjectCancer es_ES
dc.subjectPredictiones_ES
dc.subjectAdiposityes_ES
dc.subjectSizees_ES
dc.titleA Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohortes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41598-020-71302-5
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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