Night Shift Work, Chronotype, Sleep Duration, and Prostate Cancer Risk: CAPLIFE Study
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Lozano Lorca, Macarena; Olmedo Requena, María Rocío; Vega Galindo, María Victoria; Vázquez Alonso, Fernando; Jiménez Pacheco, Antonio; Salcedo Bellido, Inmaculada; Sánchez, María José; Jiménez Moleón, José JuanMateria
Prostatic neoplasms Sleep Shift work schedule Circadian rhythms Case-control studies CAPLIFE study
Date
2020-08-29Referencia bibliográfica
Lozano-Lorca, M., Olmedo-Requena, R., Vega-Galindo, M. V., Vázquez-Alonso, F., Jiménez-Pacheco, A., Salcedo-Bellido, I., ... & Jiménez-Moleón, J. J. (2020). Night Shift Work, Chronotype, Sleep Duration, and Prostate Cancer Risk: CAPLIFE Study. International Journal of Environmental Research and Public Health, 17(17), 6300. [doi:10.3390/ijerph171763000]
Sponsorship
Regional Ministry of Health of Andalusia/Consejeria de Salud of the Junta de Andalucia PI-0514-2016; Instituto de Salud Carlos III European Union (EU) PI15/00914Abstract
To analyze the association between prostate cancer (PCa) risk and night shift work,
chronotype, and sleep duration in the context of a population-based case-control study of incident prostate cancer in Spain, a total of 465 PCa cases and 410 controls were analyzed. Selection criteria were: (i) age 40–80 years, and (ii) residence in the coverage area of the reference hospitals for 6 months before recruitment. Exposure variables were: (i) night shift work (permanent or rotating); (ii) chronotype: morning, neither, or evening (Munich ChronoType Questionnaire) and (iii) sleep duration according to the recommendations of the American National Sleep Foundation. PCa aggressiveness was determined according to the International Society of Urology Pathology classification. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were estimated using logistic regression models.
Night shift work was associated with PCa, aOR = 1.47 (95% CI 1.02–2.11), especially for rotating night shifts, aOR = 1.73 (95% CI 1.09–2.75). The magnitude of the association between ever night work and PCa was higher in evening subjects with aOR = 3.14 (95% CI 0.91–10.76) than in morning chronotypes with an aOR = 1.25 (95% CI 0.78–2.00). Working night shifts, especially rotating night shifts, could increase PCa risk. This risk may be higher in people with an evening chronotyp