Mostrar el registro sencillo del ítem
Characterization of non‑linear mechanical behavior of the cornea
dc.contributor.author | Ashofteh Yazdi, A. | |
dc.contributor.author | Melchor, Juan | |
dc.contributor.author | Torres, J. | |
dc.contributor.author | Faris, Inas | |
dc.contributor.author | Calleja, Alonso | |
dc.contributor.author | Rus Carlborg, Guillermo | |
dc.date.accessioned | 2020-09-24T11:21:43Z | |
dc.date.available | 2020-09-24T11:21:43Z | |
dc.date.issued | 2020-07-14 | |
dc.identifier.citation | Yazdi, A. A., Melchor, J., Torres, J., Faris, I., Callejas, A., Gonzalez-Andrades, M., & Rus, G. (2020). Characterization of non-linear mechanical behavior of the cornea. Scientific Reports, 10(1), 1-10. [https://doi.org/10.1038/s41598-020-68391-7] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/63536 | |
dc.description.abstract | The objective of this study was to evaluate which hyperelastic model could best describe the nonlinear mechanical behavior of the cornea, in order to characterize the capability of the non-linear model parameters to discriminate structural changes in a damaged cornea. Porcine corneas were used, establishing two diferent groups: control (non-treated) and NaOH-treated (damaged) corneas (n= 8). NaOH causes a chemical burn to the corneal tissue, simulating a disease associated to structural damage of the stromal layer. Quasi-static uniaxial tensile tests were performed in nasaltemporal direction immediately after preparing corneal strips from the two groups. Three non-linear hyperelastic models (i.e. Hamilton-Zabolotskaya model, Ogden model and Mooney-Rivlin model) were ftted to the stress–strain curves obtained in the tensile tests and statistically compared. The corneas from the two groups showed a non-linear mechanical behavior that was best described by the Hamilton-Zabolotskaya model, obtaining the highest coefcient of determination (R2 > 0.95). Moreover, Hamilton-Zabolotskaya model showed the highest discriminative capability of the nonlinear model parameter (Parameter A) for the tissue structural changes between the two sample groups (p= 0.0005). The present work determines the best hyperelastic model with the highest discriminative capability in description of the non-linear mechanical behavior of the cornea. | es_ES |
dc.description.sponsorship | Ministry of Education DPI2017-83859-R DPI2014-51870-R EQC2018004508-P UNGR15-CE-3664 | es_ES |
dc.description.sponsorship | Ministry of Health - Turkey DTS15/00093 | es_ES |
dc.description.sponsorship | Junta de Andalucia PI16/00339 PI-0107-2017 PIN-0030-2017 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Research | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | Characterization of non‑linear mechanical behavior of the cornea | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1038/s41598-020-68391-7 |