Standardization procedure for fow cytometry data harmonization in prospective multicenter studies

Alarcón Riquelme, Marta Eugenia; Le Lann, Lucas

doi:10.1038/s41598-020-68468-3

s41598-020-68468-3.pdf (1.819Mb)

Identificadores

URI: http://hdl.handle.net/10481/63535

DOI: 10.1038/s41598-020-68468-3

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Editorial

Nature Research

Date

2020-07-14

Referencia bibliográfica

Le Lann, L., Jouve, P. E., Alarcón-Riquelme, M., Jamin, C., & Pers, J. O. (2020). Standardization procedure for flow cytometry data harmonization in prospective multicenter studies. Scientific reports, 10(1), 1-8. [https://doi.org/10.1038/s41598-020-68468-3]

Sponsorship

Innovative Medicines Initiative Joint Undertaking 115565; French National Research Agency (ANR) ANR-11-LABX-0016-001; Region Bretagne; European Union (EU); EFPIA companies'

Abstract

One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers of leukocyte populations and further the mean fuorescence intensities of cell markers, especially when the data are generated from diferent instruments. Here, we describe an innovative standardization workfow to compare all data to carry out any large-scale, prospective multicentric fow cytometry analysis whatever the duration, the number or type of instruments required for the realization of such projects.

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