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dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorAsady, Samara
dc.contributor.authorToledano Osorio, Manuel 
dc.contributor.authorBenítez García, José A.
dc.contributor.authorOsorio Ruiz, Raquel 
dc.date.accessioned2020-09-14T08:44:54Z
dc.date.available2020-09-14T08:44:54Z
dc.date.issued2020-06-04
dc.identifier.citationToledano, M., Asady, S., Toledano-Osorio, M., García-Godoy, F., Serrera-Figallo, M. A., Benítez-García, J. A., & Osorio, R. (2020). Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration. Polymers, 12(6), 1290. [doi:10.3390/polym12061290]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/63407
dc.description.abstractNative collagen-based membranes are used to guide bone regeneration; but due to their rapid biodegradation, this treatment is often unpredictable. The purpose of this study was to investigate the biodegradability of natural collagen membranes. Three non-cross-linked resorbable collagen barrier membranes were tested: Derma Fina (porcine dermis), Evolution Standard (equine pericardium) and Duo-Teck (equine lyophilized collagen felt). 10 × 10 mm2 pieces of membranes were submitted to three different degradation procedures: (1) hydrolytic degradation in phosphate buffer solution, (2) enzyme resistance, using a 0.25% porcine trypsin solution, and (3) bacterial (Clostridium histolyticum) collagenase resistance test. Weight measurements were performed with an analytic microbalance. Thickness was measured with a digital caliper. Membranes were analyzed at different time-points, up to 21 d of immersion. A stereomicroscope was used to obtain membranes’ images. ANOVA and Student Newman Keuls were used for mean comparisons (p < 0.05), except when analyzing differences between time-points within the same membrane and solution where pair-wise comparisons were applied (p < 0.001). Derma Fina attained the highest resistance to all degradation challenges. Duo-Teck was the most susceptible membrane to degradation, complete degradation occurred as soon as 8 h. The bacterial collagenase solution performed as the most aggressive test as all membranes presented 100% degradation before 21 d.es_ES
dc.description.sponsorshipMinistry of Economy and Competitiveness from Spain MINECO/FEDER MAT2017-85999Pes_ES
dc.description.sponsorshipEuropean Union (EU) MINECO/FEDER MAT2017-85999Pes_ES
dc.description.sponsorshipRegional Government of Andalusia Research Fund from Spain A-BIO-157-UGR-18es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectCollagen es_ES
dc.subjectMembraneses_ES
dc.subjectBiodegradation es_ES
dc.subjectBone regenerationes_ES
dc.titleDifferential Biodegradation Kinetics of Collagen Membranes for Bone Regenerationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doidoi:10.3390/polym12061290


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España