Evaluation of Novel Doxorubicin-Loaded Magnetic Wax Nanocomposite Vehicles as Cancer Combinatorial Therapy Agents
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Magnetic nanocompositesMagnetic HyperthermiaCombinatorial therapy3D in vitro modelsDrug Delivery
Jiménez-López, J., García-Hevia, L., Melguizo, C., Prados, J., Bañobre-López, M., & Gallo, J. (2020). Evaluation of Novel Doxorubicin-Loaded Magnetic Wax Nanocomposite Vehicles as Cancer Combinatorial Therapy Agents. Pharmaceutics, 12(7), 637. [doi:10.3390/pharmaceutics12070637]
Sponsorship"Local specific treatment of triple-negative-breast-cancer through externally triggered target-less drug carriers" project - FCT 031142; ERDF through NORTE2020; Portuguese Foundation for Science and Technology UTAP-EXPL/NTec/0038/2017; 2014-2020 INTERREG Cooperation Programme Spain-Portugal (POCTEP) 0624_2IQBIONEURO_6_E
The development of nanotechnology-based solutions for cancer at a preclinical level advances at an astounding pace. So far, clinical translation of these new developments has not been able to keep the pace due to a range of different reasons. One of them is the mismatch between in vitro and in vivo results coming from the expected difference in complexity. To overcome this problem, extensive characterisation using advanced in vitro models can lead to stronger preliminary data to face in vivo tests. Here, a comprehensive in vitro validation of a combinatorial therapy nanoformulation against solid tumours is presented. The information extracted from the different in vitro models highlights the importance of advanced 3D models to fully understand the potential of this type of complex drugs.