Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
Metadatos
Mostrar el registro completo del ítemAutor
Steffensen, Inger Lise; Fernández Cabrera, Mariana Fátima; Mustieles Miralles, Vicente; Rodríguez Carrillo, AndreaEditorial
MDPI
Materia
Adverse outcome pathway (AOP) Analytic methods Antioxidant Bisphenol F (BPF) Bisphenol S (BPS) Effect biomarker HBM4EU 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA) Reactive nitrogen species (RNS) Reactive oxygen species (ROS)
Fecha
2020-05Referencia bibliográfica
Steffensen, I. L., Dirven, H., Couderq, S., David, A., D’Cruz, S. C., Fernández, M. F., ... & Hofer, T. (2020). Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers. International Journal of Environmental Research and Public Health, 17(10), 3609. [DOI: 10.3390/ijerph17103609]
Patrocinador
HBM4EU project - European Union's Horizon 2020 research and innovation program 733032Resumen
Bisphenols, particularly bisphenol A (4,40
-(hexafluoroisopropylidene)-diphenol) (BPA),
are suspected of inducing oxidative stress in humans, which may be associated with adverse health
outcomes. We investigated the associations between exposure to bisphenols and biomarkers of
oxidative stress in human studies over the last 12 years (2008-2019) related to six health endpoints
and evaluated their suitability as effect biomarkers. PubMed database searches identified 27 relevant
articles that were used for data extraction. In all studies, BPA exposure was reported, whereas
some studies also reported other bisphenols. More than a dozen different biomarkers were
measured. The most frequently measured biomarkers were 8-oxo-7,8-dihydro-20
-deoxyguanosine
(8-OHdG), 8-iso-prostaglandin F2α (8-isoprostane) and malondialdehyde (MDA), which almost
always were positively associated with BPA. Methodological issues were reported for MDA, mainly
the need to handle samples with caution to avoid artefact formation and its measurements using
a chromatographic step to distinguish it from similar aldehydes, making some of the MDA results
less reliable. Urinary 8-OHdG and 8-isoprostane can be considered the most reliable biomarkers of
oxidative stress associated with BPA exposure. Although none of the biomarkers are considered BPAor organ-specific, the biomarkers can be assessed repeatedly and non-invasively in urine and could
help to understand causal relationships.