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dc.contributor.authorAmaro Gahete, Francisco José 
dc.contributor.authorJurado Fasoli, Lucas 
dc.contributor.authorRuiz Ruiz, Jonatan 
dc.contributor.authorCastillo Garzón, Manuel
dc.identifier.citationAmaro-Gahete, F. J., Jurado-Fasoli, L., Ruiz, J. R., & Castillo, M. J. (2020). Association of Basal Metabolic Rate and Nutrients Oxidation with Cardiometabolic Risk Factors and Insulin Sensitivity in Sedentary Middle-Aged Adults. Nutrients, 12(4), 1186. [doi:10.3390/nu12041186]es_ES
dc.descriptionWe acknowledge Prof. Ángel Gutiérrez Saínz for his support. This study is part of a Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.es_ES
dc.description.abstractThis cross-sectional study aimed to examine the association of basal metabolic rate (BMR) and basal fat and carbohydrate oxidation (BFox and BCHox, respectively) with cardiometabolic risk factors and insulin sensitivity in sedentary middle-aged adults. A total of 71 healthy sedentary adults (37 women) aged 40–65 years participated in the current study. Data were collected during the baseline assessments of the FIT-AGEING randomized controlled trial. BMR was measured via indirect calorimetry, and BFox and BCHox estimated by stoichiometric equations. Blood pressure, glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides plasma levels were selected as cardiometabolic risk factors and assessed following standard procedures. We observed positive associations of BMR with plasma insulin and the homeostatic model assessment of insulin resistance index (HOMA; all p < 0.05) which were attenuated or disappeared after controlling by sex, age, and/or lean mass. There were positive associations between BFox and the quantitative insulin sensitivity check index (QUICKI; p < 0.015), while negative associations were noted between BFox and plasma insulin and HOMA (p < 0.015). There was a significant negative association between BCHox with QUICKI (p < 0.01), whereas significant positive relationships were obtained when BCHox was associated with plasma insulin and HOMA (p < 0.01). These associations persisted in almost all cases when controlling by sex, age and/or lean mass. No further relationships were found when BMR, BFox, and BCHox were associated with other cardiometabolic risk factors. In conclusion, our study findings support that greater BFox and lower BCHox are related to improved insulin sensitivity, whereas BMR seems to be not associated with neither cardiometabolic risk nor insulin sensitivity in sedentary middle-aged adults. Further intervention studies are necessary to well-understand the physiological mechanism implied in this relationship.es_ES
dc.description.sponsorshipThe study is supported by the Spanish Ministry of Education (FPU14/04172 and FPU15/03960), the Redes Temáticas de Investigación Cooperativa RETIC network (Red SAMID RD16/0022), the University of Granada’s Plan Propio de Investigación 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds (ERDF, SOMM17/6107/UGR).es_ES
dc.rightsAtribución 3.0 España*
dc.subjectMetabolic ratees_ES
dc.subjectBasal metabolismes_ES
dc.subjectFat oxidationes_ES
dc.subjectCarbohydrate oxidationes_ES
dc.subjectIndirect calorimetryes_ES
dc.subjectCardiometabolic riskes_ES
dc.subjectEnergy balancees_ES
dc.subjectInsulin resistancees_ES
dc.titleAssociation of Basal Metabolic Rate and Nutrients Oxidation with Cardiometabolic Risk Factors and Insulin Sensitivity in Sedentary Middle-Aged Adultses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España