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dc.contributor.authorNavas, Arturo
dc.contributor.authorJannus, Fatin
dc.contributor.authorFernández, Belén
dc.contributor.authorMedina-O'Donnell, Marta
dc.contributor.authorDíaz Ruiz, Luis
dc.contributor.authorSánchez González, Cristina 
dc.contributor.authorLlopis González, Juan 
dc.contributor.authorRufino Palomares, Eva 
dc.contributor.authorLupiáñez Cara, José Antonio 
dc.contributor.authorQuiles Morales, José Luis 
dc.contributor.authorReyes Zurita, Fernando Jesús 
dc.contributor.authorRodríguez Diéguez, Antonio 
dc.date.accessioned2020-06-12T12:50:12Z
dc.date.available2020-06-12T12:50:12Z
dc.date.issued2020
dc.identifier.citationNavas, A., Jannus, F., Fernández, B., Cepeda, J., Medina O’Donnell, M., Díaz-Ruiz, L., ... & Lupiáñez, J. A. (2020). Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects. International Journal of Molecular Sciences, 21(9), 3146. [doi:10.3390/ijms21093146]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/62459
dc.description.abstractWe have designed and synthesized two novel cobalt coordination compounds using bumetanide (bum) and indomethacin (ind) therapeutic agents. The anti-inflammatory effects of cobalt metal complexes with ind and bum were assayed in lipopolysaccharide stimulated RAW 264.7 macrophages by inhibition of nitric oxide production. Firstly, we determined the cytotoxicity and the anti-inflammatory potential of the cobalt compounds and ind and bum ligands in RAW 264.7 cells. Indomethacin-based metal complex was able to inhibit the NO production up to 35% in a concentration-dependent manner without showing cytotoxicity, showing around 6–37 times more effective than indomethacin. Cell cycle analysis showed that the inhibition of NO production was accompanied by a reversion of the differentiation processes in LPS-stimulated RAW 264.7 cells, due to a decreased of cell percentage in G0/G1 phase, with the corresponding increase in the number of cells in S phase. These two materials have mononuclear structures and show slow relaxation of magnetization. Moreover, both compounds show anti-diabetic activity with low in vitro cell toxicities. The formation of metal complexes with bioactive ligands is a new and promising strategy to find new compounds with high and enhanced biochemical properties and promises to be a field of great interest.es_ES
dc.description.sponsorshipThis work has been funded by Junta de Andalucía (FQM-394 and FQM-1484), the Spanish Ministry of Economy and Competitiveness (MCIU/AEI/FEDER, UE) (PGC2018-102052-A-C22, PGC2018-102052-B-C21, and PGC2018-102047-B-I00) and Red Guipuzcoana de Ciencia, Tecnología e Innovación (OF188/2017), University of the Basque Country (GIU 17/13). The authors thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectBumetadinees_ES
dc.subjectIndomethacines_ES
dc.subjectCobalt es_ES
dc.subjectCoordination compounds es_ES
dc.subjectSingle ion magnetes_ES
dc.subjectInflammatoryes_ES
dc.subjectDiabetes es_ES
dc.titleDesigning Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effectses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doidoi:10.3390/ijms21093146


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España