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dc.contributor.authorZavala-Crichton, Juan Pablo
dc.contributor.authorEsteban Cornejo, Irene 
dc.contributor.authorSolis-Urra, Patricio
dc.contributor.authorMora-Gonzalez, Jose
dc.contributor.authorCadenas Sánchez, Cristina 
dc.contributor.authorRodriguez-Ayllon, Maria
dc.contributor.authorMigueles Hidalgo, Jairo 
dc.contributor.authorMolina-Garcia, Pablo
dc.contributor.authorVerdejo Román, Juan 
dc.contributor.authorCatena Martínez, Andrés 
dc.contributor.authorOrtega Porcel, Francisco Bartolomé 
dc.date.accessioned2020-06-05T10:17:50Z
dc.date.available2020-06-05T10:17:50Z
dc.date.issued2020
dc.identifier.citationZavala-Crichton, J. P., Esteban-Cornejo, I., Solis-Urra, P., Mora-Gonzalez, J., Cadenas-Sanchez, C., Rodriguez-Ayllon, M., ... & Hillman, C. H. (2020). Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project. Journal of clinical medicine, 9(4), 1101. [doi:10.3390/jcm9041101]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/62374
dc.description.abstractWe investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (β ranging −0.314 to −0.489 and cluster size 106 to 323 voxels; p < 0.001), playing video games in three brain regions (β ranging −0.391 to −0.359, and cluster size 96 to 461 voxels; p < 0.001) and total sedentary time in two brain regions (β ranging −0.341 to −0.352, and cluster size 897 to 2455 voxels; p < 0.001). No brain regions showed a significant positive association (all p > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.es_ES
dc.description.sponsorshipThis work study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund (ERDF), European Union's 2020 research and innovation program under grant agreement No. 667302 and the Alicia Koplowitz Foundation. This study was partially funded by the UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence; Scientific Unit of Excellence on Excercise and Health (UCEES) and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN I+D+I 2017-2021 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion, the European Regional Development Fund (ERDF) (Ref. RD16/0022), the EXERNET Research Network on Exercise and Health in Special Populations (DEP2005-00046/ACTI). IE-C is supported by a grant from the Alicia Koplowitz Foundation and by the Spanish Ministry of Economy and Competitiveness (RTI2018-095284-J-100)). CC-S is supported by the Regional Government of Andalusia, Integrated Territorial Initiative 2014-2020 of the province of Cadiz (PI-0002-2017) and the Spanish Ministry of Science and Innovation (FJC2018-037925-I). JHM and JM-G are supported by the Spanish Ministry of Education, Culture and Sport (FPU15/02645 and FPU14/06837, respectively). P-MG is supported by Horizon 2020 Framework Programme (Grant/Award Number: 667302). PS-U was supported by a grant from CONICYT/BECAS Chile/72180543. JVR is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). This work is part of the Juan Pablo Zavala-Crichton Ph.D. Thesis conducted in the Official Doctoral Programme in Biomedicine of the University of Granada, Spain.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationEU/H2020/667302es_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectSedentarinesses_ES
dc.subjectTelevision viewinges_ES
dc.subjectMagnetic resonance imaging es_ES
dc.subjectBrain es_ES
dc.subjectCognitiones_ES
dc.subjectChildhoodes_ES
dc.subjectObesity es_ES
dc.titleAssociation of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Projectes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doidoi:10.3390/jcm9041101


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Atribución 3.0 España
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