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dc.contributor.authorCadenas Sánchez, Cristina
dc.contributor.authorEsteban Cornejo, Irene
dc.contributor.authorMigueles, Jairo H
dc.contributor.authorVerdejo Román, Juan
dc.contributor.authorMora González, José Rafael
dc.contributor.authorKramer, Arthur F.
dc.contributor.authorCatena Martínez, Andrés 
dc.contributor.authorOrtega Porcel, Francisco Bartolomé
dc.identifier.citationCadenas-Sanchez, C., Esteban-Cornejo, I., Migueles, J. H., Labayen, I., Verdejo-Román, J., Mora-Gonzalez, J., ... & Erickson, K. I. (2020). Differences in Brain Volume between Metabolically Healthy and Unhealthy Overweight and Obese Children: The Role of Fitness. Journal of clinical medicine, 9(4), 1059. [doi: 10.3390/jcm9041059]es_ES
dc.description.abstractThe aim of this study was to examine whether metabolically healthy overweight/obese children have greater global and regional gray matter volumes than their metabolically unhealthy peers. We further examined the association between gray matter volume and academic achievement, along with the role of cardiorespiratory fitness in these associations. A total of 97 overweight/obese children (10.0 ± 1.2 years) participated. We classified children as metabolically healthy/unhealthy based on metabolic syndrome cut-offs. Global and regional brain volumes were assessed by magnetic resonance imaging. Academic achievement was assessed using the Woodcock-Muñoz standardized test. Cardiorespiratory fitness was assessed by the 20 m shuttle run test. Metabolically healthy overweight/obese (MHO) children had greater regional gray matter volume compared to those who were metabolically unhealthy (MUO) (all p ≤ 0.001). A similar trend was observed for global gray matter volume (p = 0.06). Global gray matter volume was positively related to academic achievement (β = 0.237, p = 0.036). However, all the associations were attenuated or disappeared after adjusting for cardiorespiratory fitness (p > 0.05). The findings of the present study support that metabolically healthy overweight/obese children have greater gray matter volume compared to those that are metabolically unhealthy, which is in turn related to better academic achievement. However, cardiorespiratory fitness seems to explain, at least partially, these findings.es_ES
dc.description.sponsorshipThe ActiveBrains project was funded by the Spanish Ministry of Economy and Competitiveness and the "Fondo Europeo de Desarrollo Regional (FEDER)" (DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP and RYC-2011-09011). CC-S are supported by the Government of Andalusian, Integrated Territorial Initiative 2014-2020 for the province of Cadiz (PI-0002-2017) and the Spanish Ministry of Science and Innovation (FJC2018-037925-I). IE-C are supported by the Alicia Koplowitz Foundation and the Spanish Ministry of Economy and Competitiveness (RTI2018-095284-J-100). JHM and JM-G are supported by the Spanish Ministry of Education, Culture and Sport (FPU15/02645 and FPU14/06837, respectively). JVR is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). PH was supported by a grant from the Strategic Research Area Health Care Science, Karolinska Institutet/Umea University. Additional funding was obtained from the University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence; Scientific Excellence Unit on Exercise and Health (UCEES). Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades and European Regional Development Funds (ref. SOMM17/6107/UGR). In addition, funding was provided by the SAMID III network, RETICS, funded by the PN I + D + I 2017-2021 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion, the European Regional Development Fund (ERDF) (Ref. RD16/0022), the EXERNET Research Network on Exercise and Health in Special Populations (DEP2005-00046/ACTI) and the European Union's 2020 research and innovation program under grant agreement No 667302.es_ES
dc.rightsAtribución 3.0 España*
dc.subjectAcademic achievement es_ES
dc.subjectCardiorespiratory fitnesses_ES
dc.subjectGlobal volumees_ES
dc.subjectGray matteres_ES
dc.subjectRegional volumees_ES
dc.titleDifferences in Brain Volume between Metabolically Healthy and Unhealthy Overweight and Obese Children: The Role of Fitnesses_ES
dc.identifier.doidoi: 10.3390/jcm9041059]

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España