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dc.contributor.authorObón-Santacana, Mireia
dc.contributor.authorOlmedo Requena, María Rocío 
dc.contributor.authorLozano Lorca, Macarena
dc.date.accessioned2020-05-14T08:10:17Z
dc.date.available2020-05-14T08:10:17Z
dc.date.issued2019-06-21
dc.identifier.citationObón-Santacana, M.; Romaguera, D.; Gracia-Lavedan, E.; Molinuevo, A.; Molina-Montes, E.; Shivappa, N.; Hebert, J.R.; Tardón, A.; Castaño-Vinyals, G.; Moratalla, F.; Guinó, E.; Marcos-Gragera, R.; Azpiri, M.; Gil, L.; Olmedo-Requena, R.; Lozano-Lorca, M.; Alguacil, J.; Fernández-Villa, T.; Martín, V.; Molina, A.J.; Ederra, M.; Moreno-Iribas, C.; Perez, B.; Aragonés, N.; Castello, A.; Huerta, J.M.; Dierssen-Sotos, T.; Gómez-Acebo, I.; Molina-Barceló, A.; Pollán, M.; Kogevinas, M.; Moreno, V.; Amiano, P. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients 2019, 11, 1406. [doi:10.3390/nu11061406]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/62056
dc.descriptionThe following are available online at https://www.mdpi.com/2072-6643/11/6/1406/s1, Table S1: Association E-DII and dietary NEAC and colorectal and breast cancer in the MCC-Spain Study. Table S2: Stratified analyses: OR and 95%CI for E-DII score and dietary NEAC and colorectal and breast cancer risk in the MCC-Spain Studyes_ES
dc.descriptionWe appreciate the collaboration of all those who participated providing questionnaire data. We thank all MCC-Spain study group members and collaborators.es_ES
dc.descriptionThis research was partially funded by the public grants from the Catalan Government (2014SGR756, 2017SGR1085, 2017SGR733, SLT006/17/76), and European Regional Development Fund-ERDF, by the “Acción Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17-00092), by the Fundación Marqués de Valdecilla (API 10/09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII(RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation – grant GCTRA18022MORE, by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) grants 2014SGR647, 2014SGR850 and 2017SGR723. Sample collection of this work was supported by the Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d’Oncología de Catalunya (XBTC)”, Plataforma Biobancos PT13/0010/0013" and ICOBIOBANC, sponsored by the Catalan Institute of Oncology. We thank CERCA Program, Generalitat de Catalunya for institutional support. Mireia Obón-Santacana received a post-doctoral fellow from “Fundación Científica de la Asociación Española Contra el Cáncer (AECC)”.es_ES
dc.description.abstractInflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99–1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.es_ES
dc.description.sponsorshipGrants from the Catalan Government (2014SGR756, 2017SGR1085, 2017SGR733, SLT006/17/76), and European Regional Development Fund-ERDF, by the “Acción Transversal del Cancer”es_ES
dc.description.sponsorshipInstituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17-00092)es_ES
dc.description.sponsorshipFundación Marqués de Valdecilla (API 10/09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII(RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation – grant GCTRA18022MORE, by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) grants 2014SGR647, 2014SGR850 and 2017SGR723es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectColorectal canceres_ES
dc.subjectbreast canceres_ES
dc.subjectDiet es_ES
dc.subjectDietary inflammatory indexes_ES
dc.subjectAntioxidants es_ES
dc.subjectNEACes_ES
dc.subjectCase-control studyes_ES
dc.subjectMCC-Spaines_ES
dc.titleDietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu11061406


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