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dc.contributor.authorPlaza Díaz, Julio 
dc.contributor.authorÁlvarez Mercado, Ana Isabel 
dc.contributor.authorRuiz Marín, Carmen
dc.contributor.authorReina Pérez, Iris 
dc.contributor.authorPérez Alonso, Alejandro José
dc.contributor.authorTorné Poyatos, Pablo 
dc.contributor.authorGallart Aragón, Tania 
dc.contributor.authorSánchez-Barrón, María Teresa
dc.contributor.authorReyes Lartategui, S. de
dc.contributor.authorGarcía, Federico
dc.contributor.authorChueca-Porcuna, Natalia
dc.contributor.authorSáez Lara, María José 
dc.contributor.authorRobles-Sánchez, Candido
dc.contributor.authorFernández, Mariana F.
dc.contributor.authorFontana Gallego, Luis 
dc.date.accessioned2020-05-11T12:48:18Z
dc.date.available2020-05-11T12:48:18Z
dc.date.issued2019-05-24
dc.identifier.citationPlaza-Díaz, J., Álvarez-Mercado, A.I., Ruiz-Marín, C. et al. Association of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical study. BMC Cancer 19, 495 (2019). [https://doi.org/10.1186/s12885-019-5660-y]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/61954
dc.descriptionWe would like to thank M Luisa Puertas-Martin and Isabel Manzano-Jimenez, nurses at the Unit of Mammary Pathology, General Surgery Service, San Cecilio University Hospital (Granada), without whose enthusiasm the enrolment of participants in Granada would still be stalled. We are indebted to all the women taking part in the study.es_ES
dc.descriptionThe funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.descriptionTrial registration ClinicalTrials.gov NCT03885648, 03/25/2019. Retrospectively registered.es_ES
dc.description.abstractBackground Breast cancer ranks first in women, and is the second cause of death in this gender. In addition to genetics, the environment contributes to the development of the disease, although the factors involved are not well known. Among the latter is the influence of microorganisms and, therefore, attention is recently being paid to the mammary microbiota. We hypothesize that the risk of breast cancer could be associated with the composition and functionality of the mammary/gut microbiota, and that exposure to environmental contaminants (endocrine disruptors, EDCs) might contribute to alter these microbiota. Methods We describe a case-control clinical study that will be performed in women between 25 and 70 years of age. Cases will be women diagnosed and surgically intervened of breast cancer (stages I and II). Women with antecedents of cancer or advanced tumor stage (metastasis), or who have received antibiotic treatment within a period of 3 months prior to recruitment, or any neoadjuvant therapy, will be excluded. Controls will be women surgically intervened of breast augmentation or reduction. Women with oncological, gynecological or endocrine history, and those who have received antibiotic treatment within a period of 3 months prior to recruitment will also be excluded. Blood, urine, breast tissue and stool samples will be collected. Data regarding anthropometric, sociodemographic, reproductive history, tumor features and dietary habits will be gathered. Metabolomic studies will be carried out in stool and breast tissue samples. Metagenomic studies will also be performed in stool and breast tissue samples to ascertain the viral, fungal, bacterial and archaea populations of the microbiota. Quantitation of estrogens, estrogen metabolites and EDCs in samples of serum, urine and breast tissue will also be performed. Discussion: This is the first time that the contribution of bacteria, archaea, viruses and fungi together with their alteration by environmental contaminants to the risk of breast cancer will be evaluated in the same study. Results obtained could contribute to elucidate risk factors, improve the prognosis, as well as to propose novel intervention studies in this disease.es_ES
dc.description.sponsorshipThis work is funded by grants PI-0538-2017 (Junta de Andalucía, Spain, to LF) and Biomedical Research Networking Center-CIBER de Epidemiología y Salud Pública (CIBERESP) of the Institute of Health Carlos III -supported by European Regional Development Fund/FEDER (FIS-PI16/01812) (to MFF).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectArchaeaes_ES
dc.subjectBacteria es_ES
dc.subjectBreast canceres_ES
dc.subjectBreast microbiotaes_ES
dc.subjectEndocrine disruptorses_ES
dc.subjectEnvironmental pollutantses_ES
dc.subjectFungi es_ES
dc.subjectGut microbiotaes_ES
dc.subjectVirus es_ES
dc.titleAssociation of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1186/s12885-019-5660-y


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