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dc.contributor.authorBaken, Kirsten A.
dc.contributor.authorMustieles Miralles, Vicente
dc.contributor.authorRodríguez-Carrillo, Andrea
dc.contributor.authorOlea Serrano, Nicolás
dc.identifier.citationBaken, K. A., Lambrechts, N., Remy, S., Mustieles, V., Rodríguez-Carrillo, A., Neophytou, C. M., ... & Schoeters, G. (2019). A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects. Environmental research, 175, 235-256.es_ES
dc.description.abstractHuman biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.es_ES
dc.description.sponsorshipThis project has received funding from the European Unions' Horizon 2020 research and innovation Programme under grant agreement No 733032 HBM4EUes_ES
dc.publisherElsevier Inc.es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.titleA strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effectses_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España