Mostrar el registro sencillo del ítem
Article Germacrone Derivatives as new Insecticidal and Acaricidal Compounds: A Structure-Activity Relationship
dc.contributor.author | Galisteo Pretel, Alberto | |
dc.contributor.author | Pérez del Pulgar, Helena | |
dc.contributor.author | Fernández Barrero, Alejandro | |
dc.contributor.author | Quílez Del Moral, José Francisco | |
dc.date.accessioned | 2020-04-22T06:34:41Z | |
dc.date.available | 2020-04-22T06:34:41Z | |
dc.date.issued | 2019-08-09 | |
dc.identifier.citation | Galisteo Pretel, A.; Pérez del Pulgar, H.; Guerrero de León, E.; López-Pérez, J.L.; Olmeda, A.S.; Gonzalez-Coloma, A.; F. Barrero, A.; Quílez del Moral, J.F. Germacrone Derivatives as new Insecticidal and Acaricidal Compounds: A Structure-Activity Relationship. Molecules 2019, 24, 2898. [doi:10.3390/molecules24162898] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/61450 | |
dc.description | The supplementary material related to this article includes NMR spectra of new compounds is available online at https://www.mdpi.com/1420-3049/24/16/2898/s1. | es_ES |
dc.description.abstract | Currently, the use of synthetic pesticides is the main method of plant protection applied in agri- and horticulture. However, its excessive use leads to the development of pesticide resistance, a contamination of the environment, toxicity to non-target organisms, and risks for human health. With the ultimate aim of contributing to the develop of a more sustainable pest management, we used the natural product germacrone (compound 1), reported to possess significant insecticidal activity, as starting material for the generation of molecular diversity (2–24). Some of the generated derivatives are natural compounds, such as 1,10-epoxygermacrone (2), 4,5-epoxygermacrone (3), gajutsulactone A (7), germacrol (11), isogermacrone (14), 9-hydroxyeudesma-3,7(11)dien-6-one (19), eudesma-4,7(11),dien-8-one (20), eudesma-3,7(11)-dien-8-one (21) and eudesma-4(15),7(11)-dien-8-one (22). Compounds, 7,11-9,10-diepoxigermacr-4,5-en-8-ol (17), 7,11-epoxieudesma-4,7(11)-dien-8-one (23) and 7,11-epoxieudesma-3,7(11)-dien-8-one (24) are described for the first time. The biocidal activity of most of these compounds was assayed against the tick Hyalomma lusitanicum. The acaricidal effects of compound 24 were four times higher than that of germacrone (1). Compound 2 is an insect antifeedant a thousand times more potent than germacrone against Rhopalosiphum padi, which makes this substance a promising selective antifeedant against this cereal pest. | es_ES |
dc.description.sponsorship | This research was funded by Grant CTQ-2015-64049-C3-3-R/CTQ2015-64049-C3-1-R; MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD, Spain (MINECO/FEDER). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Natural products | es_ES |
dc.subject | Organic synthesis | es_ES |
dc.subject | Bioactive compounds | es_ES |
dc.subject | Insecticidal | es_ES |
dc.subject | Ixodicidal | es_ES |
dc.title | Article Germacrone Derivatives as new Insecticidal and Acaricidal Compounds: A Structure-Activity Relationship | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/molecules24162898 |