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dc.contributor.authorAwad, Mahmoud E.
dc.contributor.authorLópez Galindo, Alberto
dc.contributor.authorMedarevic, Djordje
dc.contributor.authorDuris, Jelena
dc.contributor.authorEl-Rahmany, Mahmoud M.
dc.contributor.authorIbric, Svetlana
dc.contributor.authorViseras Iborra, César Antonio 
dc.date.accessioned2020-04-21T11:56:17Z
dc.date.available2020-04-21T11:56:17Z
dc.date.issued2019-12-26
dc.identifier.citationAwad, M. E., López-Galindo, A., Medarević, D., Đuriš, J., El-Rahmany, M. M., Ibrić, S., & Viseras, C. (2020). Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients. Minerals, 10(1), 23.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/61425
dc.description.abstractThe present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected based on kaolinite richness and their structural order-disorder degree, and after purification, they were dried at 70 ºC and heated from room temperature up to 400 ºC (10 ºC/min). Mineralogy, micromorphology, microtexture, granulometry, porosimetry, moisture content, bulk and tapped density, direct and indirect flowability, and tableting characteristics are studied. Results indicated that purified kaolin samples were made up of 95–99% kaolinite, <3% illite, 1% quartz and 1% anatase. The powder showed mesoporous character (pore diameters from 2 to 38 nm and total pore volume from 0.064 to 0.136 cm3/g) with dominance of fine nanosized particles (<1 um–10 nm). The powder flow characteristics of both the ordered (Hinckley Index HI > 0.7, crystallite size D001 > 30 nm) and disordered (HI < 0.7, D001 < 30 nm) kaolinite-rich samples have been improved (Hausner ratio between 1.24 and 1.09) as their densities were influenced by thermal treatment (with some observed changes in the kaolinite XRD reflection profiles) and by moisture content (variable between 2.98% and 5.82%). The obtained tablets exhibited hardness between 33 and 44 N only from the dehydrated powders at 400 ºC, with elastic recovery (ER) between 21.74% and 25.61%, ejection stress (ES) between 7.85 and 11.45 MPa and tensile fracture stress (TFS) between 1.85 and 2.32 MPa, which are strongly correlated with crystallinity (HI) and flowability (HR) parameters. These findings on quality indicators showed the promising pharmaceutical tabletability of the studied Egyptian kaolin powders and the optimization factors for their manufacturability and compactability.es_ES
dc.description.sponsorshipThis work has been funded by the Egyptian Cultural Affairs and Missions Sector (Plan 2013–2014), Ministry of Higher Education, in collaboration with the Group CTS-946 (Junta de Andalucía) and MINECO project CGL2016-80833-R (Spain), and the grant funded by Erasmus+ KA1 mobility program 2016/2017.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectEgyptian kaolines_ES
dc.subjectTableting propertieses_ES
dc.subjectMicrostructurees_ES
dc.subjectMicrometricses_ES
dc.subjectTable hardnesses_ES
dc.titleFlow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/min10010023


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