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dc.contributor.authorMartínez Téllez, Borja Manuel 
dc.contributor.authorSánchez-Delgado, Guillermo
dc.contributor.authorBoon, Mariëtte R.
dc.contributor.authorRensen, Patrick C. N.
dc.contributor.authorLlamas Elvira, José Manuel 
dc.contributor.authorRuiz Ruiz, Jonatan 
dc.date.accessioned2020-04-14T11:49:33Z
dc.date.available2020-04-14T11:49:33Z
dc.date.issued2020
dc.identifier.citationMartinez-Tellez, B., Sanchez-Delgado, G., Boon, M. R., Rensen, P. C., Llamas-Elvira, J. M., & Ruiz, J. R. (2020). Distribution of brown adipose tissue radiodensity in young adults: implications for cold [18 F] FDG-PET/CT analyses. Molecular Imaging and Biology, 22(2), 425-433.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/61179
dc.description.abstractProcedures: We measured 125 individuals after a personalized cooling protocol with a static [18F]FDG-PET/CT scan. We quantified BAT using different combination of threshold in every single HU for all participants. Results: We observed that the SUV threshold influences BAT quantification by [18F]FDG-PET/ CT scans more than the HU range. We found that the range from − 50 to − 10 HU had the highest proportion of total BAT volume (43.2 %), which represents 41.4 % of the total BAT metabolic activity in our cohort. We also observed that BAT volume was not different between categories of body mass index, as well as BAT activity (SUVmean). In addition, BAT was less dense in women than in men, although the BAT activity (SUVmean) was higher in all ranges of HU. We also observed that the radiodensity of BAT located in the cervical area was mainly in the range from − 50 to − 10 HU. Conclusion: Therefore, all future human studies using static [18F]FDG-PET/CT scans should include BAT in the radiodensity range from − 50 to − 10 HU.es_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Economy and Competitiveness, Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and Retos de la Sociedad (DEP2016-79512-R), Fondos Estructurales de la Unión Europea (FEDER), by the Spanish Ministry of Education (FPU 13/04365), by the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES) - and Plan Propio de Investigación 2018 - Programa Contratos-Puente, and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (FEDER, ref. SOMM17/6107/UGR).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectBrown fates_ES
dc.subjectHounsfield unitses_ES
dc.subjectStandardized uptake valuees_ES
dc.subjectCold exposurees_ES
dc.titleDistribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1007/s11307-019-01381-y


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