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Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses
dc.contributor.author | Martínez Téllez, Borja Manuel | |
dc.contributor.author | Sánchez-Delgado, Guillermo | |
dc.contributor.author | Boon, Mariëtte R. | |
dc.contributor.author | Rensen, Patrick C. N. | |
dc.contributor.author | Llamas Elvira, José Manuel | |
dc.contributor.author | Ruiz Ruiz, Jonatan | |
dc.date.accessioned | 2020-04-14T11:49:33Z | |
dc.date.available | 2020-04-14T11:49:33Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Martinez-Tellez, B., Sanchez-Delgado, G., Boon, M. R., Rensen, P. C., Llamas-Elvira, J. M., & Ruiz, J. R. (2020). Distribution of brown adipose tissue radiodensity in young adults: implications for cold [18 F] FDG-PET/CT analyses. Molecular Imaging and Biology, 22(2), 425-433. | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/61179 | |
dc.description.abstract | Procedures: We measured 125 individuals after a personalized cooling protocol with a static [18F]FDG-PET/CT scan. We quantified BAT using different combination of threshold in every single HU for all participants. Results: We observed that the SUV threshold influences BAT quantification by [18F]FDG-PET/ CT scans more than the HU range. We found that the range from − 50 to − 10 HU had the highest proportion of total BAT volume (43.2 %), which represents 41.4 % of the total BAT metabolic activity in our cohort. We also observed that BAT volume was not different between categories of body mass index, as well as BAT activity (SUVmean). In addition, BAT was less dense in women than in men, although the BAT activity (SUVmean) was higher in all ranges of HU. We also observed that the radiodensity of BAT located in the cervical area was mainly in the range from − 50 to − 10 HU. Conclusion: Therefore, all future human studies using static [18F]FDG-PET/CT scans should include BAT in the radiodensity range from − 50 to − 10 HU. | es_ES |
dc.description.sponsorship | This study was supported by the Spanish Ministry of Economy and Competitiveness, Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and Retos de la Sociedad (DEP2016-79512-R), Fondos Estructurales de la Unión Europea (FEDER), by the Spanish Ministry of Education (FPU 13/04365), by the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES) - and Plan Propio de Investigación 2018 - Programa Contratos-Puente, and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (FEDER, ref. SOMM17/6107/UGR). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Brown fat | es_ES |
dc.subject | Hounsfield units | es_ES |
dc.subject | Standardized uptake value | es_ES |
dc.subject | Cold exposure | es_ES |
dc.title | Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1007/s11307-019-01381-y |