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dc.contributor.authorTenorio-Jiménez, Carmen
dc.contributor.authorCamacho Páez, José 
dc.contributor.authorChueca-Porcuna, Natalia
dc.contributor.authorGarcía, Federico
dc.contributor.authorGarcía, Federico
dc.contributor.authorOlza Meneses, Josune
dc.contributor.authorPlaza Díaz, Julio
dc.contributor.authorFontana Gallego, Luis 
dc.contributor.authorOlivares Martín, Mónica
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorGómez Llorente, Carolina
dc.date.accessioned2020-03-30T09:34:30Z
dc.date.available2020-03-30T09:34:30Z
dc.date.issued2019-07-31
dc.identifier.citationTenorio-Jiménez, C.; Martínez-Ramírez, M.J.; Del Castillo-Codes, I.; Arraiza-Irigoyen, C.; Tercero-Lozano, M.; Camacho, J.; Chueca, N.; García, F.; Olza, J.; Plaza-Díaz, J.; Fontana, L.; Olivares, M.; Gil, Á.; Gómez-Llorente, C. Lactobacillus reuteri V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study. Nutrients 2019, 11, 1761. [doi:10.3390/nu11081761]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/60790
dc.descriptionThe following are available online at https://www.mdpi.com/2072-6643/11/8/1761/s1: Figure S1, Rarefaction curves; Figure S2, Alpha diversity measured by means of the Shannon index (H); Figure S3, Bacterial beta diversity; Table S1, Gastrointestinal microbiome normalized dataes_ES
dc.descriptionThis paper will be part of Carmen Tenorio Jimenez’s doctorate, which is being completed as part of Programa de Doctorado en Seguridad de los Alimentos at the University of Jaén, Spain. We also wish to thank all the participants who generously contributed to the study.es_ES
dc.description.abstractPrevious studies have reported that probiotics may improve clinical and inflammatory parameters in patients with obesity and metabolic syndrome (MetS). Lactobacillus (L.) reuteri V3401 has shown promising results on the components of MetS in animal studies. We aimed to evaluate the effects of L. reuteri V3401 together with healthy lifestyle recommendations on adult patients with MetS. Methods: We carried out a randomized, crossover, placebo-controlled, single-center trial in which we included 53 adult patients newly diagnosed with MetS. Patients were block randomly allocated by body mass index (BMI) and sex to receive a capsule containing either the probiotic L. reuteri V3401 (5 × 109 colony-forming units) or a placebo once daily for 12 weeks. Anthropometric variables, biochemical and inflammatory biomarkers, as well as the gastrointestinal microbiome composition were determined. Results: There were no differences between groups in the clinical characteristics of MetS. However, we found that interleukin-6 (IL-6) and soluble vascular cell adhesion molecule 1 (sVCAM-1) diminished by effect of the treatment with L. reuteri V3401. Analysis of the gastrointestinal microbiome revealed a rise in the proportion of Verrucomicrobia. Conclusions: Consumption of L. reuteri V3401 improved selected inflammatory parameters and modified the gastrointestinal microbiome. Further studies are needed to ascertain additional beneficial effects of other probiotic strains in MetS as well as the mechanisms by which such effects are exerted.es_ES
dc.description.sponsorshipThis study is part of the grant entitled “Guía para la sustanciación de declaraciones de salud en alimentos: funciones inmune, cognitiva y síndrome metabólico”, funded by the company Biosearch life (Granada, Spain), reference 3006, managed by Fundación General Universidad de Granada, Spain.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectMetabolic syndromees_ES
dc.subjectGastrointestinal microbiomees_ES
dc.subjectLactobacillus reuteri V3401es_ES
dc.subjectProbioticses_ES
dc.subjectObesity es_ES
dc.titleLactobacillus reuteri V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu11081761


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España