dc.contributor.author | Anguita-Ruiz, Augusto | |
dc.contributor.author | Plaza Díaz, Julio | |
dc.contributor.author | Ruiz Ojeda, Francisco Javier | |
dc.contributor.author | Rupérez Cano, Azahara Iris | |
dc.contributor.author | Leis, Rosaura | |
dc.contributor.author | Bueno, Gloria | |
dc.contributor.author | Gil-Campos, Mercedes | |
dc.contributor.author | Vázquez Cobela, Rocío | |
dc.contributor.author | Cañete, Ramón | |
dc.contributor.author | Moreno, Luis A. | |
dc.contributor.author | Gil Hernández, Ángel | |
dc.contributor.author | Aguilera García, Concepción María | |
dc.date.accessioned | 2020-03-10T10:32:48Z | |
dc.date.available | 2020-03-10T10:32:48Z | |
dc.date.issued | 2019-07-22 | |
dc.identifier.citation | Anguita-Ruiz, A., Plaza-Diaz, J., Ruiz-Ojeda, F. J., Rupérez, A. I., Leis, R., Bueno, G., ... & Gil, Á. (2019). X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline. Scientific data, 6(1), 1-10. | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/60180 | |
dc.description.abstract | X chromosome genetic variation has been proposed as a potential source of missing heritability for
many complex diseases, including obesity. Currently, there is a lack of public available genetic datasets
incorporating X chromosome genotype data. Although several X chromosome-specific statistics have
been developed, there is also a lack of readily available implementations for routine analysis. Here, we
aimed: (1) to make public and describe a dataset incorporating phenotype and X chromosome genotype
data from a cohort of 915 normal-weight, overweight and obese children, and (2) to deeply describe a
whole implementation of the special X chromosome analytic process in genetics. Datasets and pipelines
like this are crucial to get familiar with the steps in which X chromosome requires special attention and
may raise awareness of the importance of this genomic region. | es_ES |
dc.description.sponsorship | This paper will be part of Augusto Anguita-Ruiz’s doctorate, which is being completed as part of the “Nutrition
and Food Sciences Program” at the University of Granada, Spain. The authors would like to thank the children and
parents who participated in the study. This work was supported by the Plan Nacional de Investigación Científica,
Desarrollo e Innovación Tecnológica (I+D+I), Instituto de Salud Carlos III-Fondo de Investigación Sanitaria
(FONDOS FEDER) Projects numbers PI051968, PI1102042 and PI1600871, Redes temáticas de investigación
cooperativa RETIC (Red SAMID RD12/0026/0015) and the Mapfre Foundation. The authors also acknowledge
the Institute of Health Carlos III for personal funding: “Contratos i-PFIS: doctorados IIS-empresa en ciencias y
tecnologías de la salud de la convocatoria 2017 de la Acción Estratégica en Salud 2013–2016, Project number:
IFI17/00048”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | X chromosome genetic data in a Spanish children cohort, dataset description and analysis pipeline | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1038/s41597-019-0109-3 | |