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dc.contributor.authorGriñán Lisón, Carmen 
dc.contributor.authorOlivares Urbano, María Auxiliadora
dc.contributor.authorJiménez, Gema
dc.contributor.authorLópez Ruiz, Elena
dc.contributor.authorVal Muñoz, María Coral Del 
dc.contributor.authorMorata-Tarifa, Cynthia
dc.contributor.authorEntrena, José Manuel
dc.contributor.authorGonzález Ramírez, Amanda Rocío
dc.contributor.authorBoulaiz Tassi, Houria 
dc.contributor.authorZurita Herrera, Mercedes
dc.contributor.authorNúñez Torres, María Isabel 
dc.contributor.authorMarchal Corrales, Juan Antonio 
dc.date.accessioned2020-03-03T08:49:22Z
dc.date.available2020-03-03T08:49:22Z
dc.date.issued2019
dc.identifier.citationGriñán‐Lisón, C., Olivares‐Urbano, M. A., Jiménez, G., López‐Ruiz, E., del Val, C., Morata‐Tarifa, C., ... & Núñez, M. I. (2020). miRNAs as radio‐response biomarkers for breast cancer stem cells. Molecular Oncology.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/59942
dc.description.abstractIn breast cancer (BC), the presence of cancer stem cells (CSCs) has been related to relapse, metastasis, and radioresistance. Radiotherapy (RT) is an extended BC treatment, but is not always effective. CSCs have several mechanisms of radioresistance in place, and some miRNAs are involved in the cellular response to ionizing radiation (IR). Here, we studied how IR affects the expression of miRNAs related to stemness in different molecular BC subtypes. Exposition of BC cells to radiation doses of 2, 4, or 6 Gy affected their phenotype, functional characteristics, pluripotency gene expression, and in vivo tumorigenic capacity. This held true for various molecular subtypes of BC cells (classified by ER, PR and HER-2 status), and for BC cells either plated in monolayer, or being in suspension as mammospheres. However, the effect of IR on the expression of eight stemness- and radioresistance-related miRNAs (miR-210, miR-10b, miR-182, miR-142, miR-221, miR-21, miR-93, miR-15b) varied, depending on cell line subpopulation and clinicopathological features of BC patients. Therefore, clinicopathological features and, potentially also, chemotherapy regimen should be both taken into consideration, for determining a potential miRNA signature by liquid biopsy in BC patients treated with RT. Personalized and precision RT dosage regimes could improve the prognosis, treatment, and survival of BC patients.es_ES
dc.description.sponsorshipThis work has been partially funded by the Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía and European Regional Development Fund (ERDF), ref. SOMM17/6109/ UGR, and with grants from the Ministry of Economy and Competitiveness (FEDER funds, projects no. PIE16/00045) and from the Chair ‘Doctors Galera- Requena in cancer stem cell research’ (CMC-CTS963).es_ES
dc.language.isoenges_ES
dc.publisherFEBS Presses_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectBiomarkerses_ES
dc.subjectBreast canceres_ES
dc.subjectmiRNAses_ES
dc.subjectRadiotherapy es_ES
dc.subjectRadiation es_ES
dc.titlemiRNAs as radio-response biomarkers for breast cancer stem cellses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1002/1878-0261.12635


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Atribución 3.0 España
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