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dc.contributor.authorJiménez Moleón, José Juan
dc.identifier.citationPeremiquel-Trillas, P., Benavente, Y., Martín-Bustamante, M., Casabonne, D., Pérez-Gómez, B., Gómez-Acebo, I., ... & Mengual, L. (2019). Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study. Environment international, 122, 389-399.es_ES
dc.description.abstractAlkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. We carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR=1.23; 95% CI=1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR=1.28; 95% CI=1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR=1.21; 95% CI=1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.es_ES
dc.description.sponsorshipThis work was partially funded by the public grants from the Catalan Government (2014SGR756, 2017SGR1085, 2017SGR733, SLT006/17/76), and European Regional Development Fund-ERDF, by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos IIIFEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/ 01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/ 00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/ 00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/ 00049, PI17/01179), by the Fundación Marqués de Valdecilla (API 10/ 09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI- 0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) grants 2014SGR647 and 2014SGR850. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.es_ES
dc.publisherElsevier BVes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rightsAtribución 3.0 España*
dc.subjectAlkylphenolic compoundses_ES
dc.subjectJob-exposure matrixes_ES
dc.subjectBreast canceres_ES
dc.subjectProstate canceres_ES
dc.subjectOccupational exposurees_ES
dc.titleAlkylphenolic compounds and risk of breast and prostate cancer in the MCCSpain studyes_ES

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