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dc.contributor.authorMartín Blázquez, Ariadna
dc.contributor.authorDíaz, Caridad
dc.contributor.authorGonzález Flores, Encarnación
dc.contributor.authorFranco Rivas, Daniel
dc.contributor.authorJiménez Luna, Cristina 
dc.contributor.authorMelguizo Alonso, Consolación 
dc.contributor.authorPrados Salazar, José Carlos 
dc.contributor.authorGenilloud Rodríguez, Olga
dc.contributor.authorVicente, Francisca
dc.contributor.authorCaba Pérez, Octavio 
dc.contributor.authorPérez del Palacio, José
dc.date.accessioned2020-02-12T12:53:44Z
dc.date.available2020-02-12T12:53:44Z
dc.date.issued2019
dc.identifier.citationMartín-Blázquez, A., Díaz, C., González-Flores, E., Franco-Rivas, D., Jiménez-Luna, C., Melguizo, C., ... & del Palacio, J. P. (2019). Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer. Scientific Reports, 9(1), 1-9.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/59615
dc.description.abstractColorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagnostic markers for colorectal cancer and may also represent new therapeutic targets. Metabolomics generates a pathophysiological ‘fingerprint’ that is unique to each individual. The purpose of our study was to identify a differential metabolomic signature for metastatic colorectal cancer. Serum samples from 60 healthy controls and 65 patients with metastatic colorectal cancer were studied by liquid chromatography coupled to high-resolution mass spectrometry in an untargeted metabolomic approach. Multivariate analysis revealed a separation between patients with metastatic colorectal cancer and healthy controls, who significantly differed in serum concentrations of one endocannabinoid, two glycerophospholipids, and two sphingolipids. These findings demonstrate that metabolomics using liquid-chromatography coupled to high-resolution mass spectrometry offers a potent diagnostic tool for metastatic colorectal cancer.es_ES
dc.description.sponsorshipThis study was supported by a grant (n° 15CC056/DTS17/00081- ISCIII-FEDER) from the Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO) and Roche Pharma S.L. Authors from the Fundación MEDINA acknowledge the receipt of financial support from this public-private partnership of Merck Sharp & Dohme de España S.A. with the University of Granada and Andalusian Regional Government (PIN-0474-2016).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleUntargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41598-019-55952-8


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Atribución 3.0 España
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