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dc.contributor.authorLima, Luciano C. B.
dc.contributor.authorViseras Iborra, César Antonio
dc.identifier.citationLima, L. C., Coelho, C. C., Silva, F. C., Meneguin, A. B., Barud, H. S., Bezerra, R. D., ... & Silva-Filho, E. C. (2019). Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release. Materials, 12(21), 3634.es_ES
dc.description.abstractInorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g-1 for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window.es_ES
dc.description.sponsorshipThis research was funded by FAPEPI to Caio C. Coelho for Scientific Initiation scholarshipes_ES
dc.rightsAtribución 3.0 España*
dc.subjectPhyllosilicates es_ES
dc.subjectDrug releasees_ES
dc.titleHybrid Systems Based on Talc and Chitosan for Controlled Drug Releasees_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España