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dc.contributor.authorCruz López, Olga María 
dc.contributor.authorFranco Montalbán, Francisco 
dc.date.accessioned2020-01-10T10:05:18Z
dc.date.available2020-01-10T10:05:18Z
dc.date.issued2019
dc.identifier.citationCruz-López, O., Temps, C., Longo, B., Myers, S. H., Franco-Montalban, F., & Unciti-Broceta, A. (2019). Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity. ACS omega.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/58625
dc.description.abstractA novel macrocyclic construct consisting of a pyrazolopyrimidine scaffold concatenated to a benzene ring through two triazoles has been developed to investigate uncharted chemical space with bioactive potential. The 18-atom macrocycle was assembled via a double copper-catalyzed alkyne−azide cycloaddition (CuAAC) reaction between 1,3- bis(azidomethyl)benzene and a bis-propargylated pyrazolo[3,4-d]pyrimidine core. The resulting macrocycle was functionalized further into a multicyclic analog that displays selective inhibitory activity against the receptor tyrosine kinase AXL.es_ES
dc.description.sponsorshipO.C.-L. and B.L. thank Spain Ministry of Education, Culture and Sport and the Erasmus + Traineeship programme for funding, respectively. C.T. thanks the CMVM for a Principal’s Scholarship. F.F. acknowledges support from Universidad de Granada. SHM and AU-B are grateful to Scottish Power and CRUK for funding.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.rightsAtribución-NoComercial 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.titleSynthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1021/acsomega.9b03525


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