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dc.contributor.authorGalisteo Pretel, Alberto
dc.contributor.authorPérez del Pulgar, Helena
dc.contributor.authorSonia Olmeda, A.
dc.contributor.authorGonzález Coloma, Azucena
dc.contributor.authorFernández Barrero, Alejandro 
dc.contributor.authorQuílez Del Moral, José Francisco 
dc.date.accessioned2020-01-08T13:52:42Z
dc.date.available2020-01-08T13:52:42Z
dc.date.issued2019-11-16
dc.identifier.citationGalisteo Pretel, A., Pérez del Pulgar, H., Olmeda, A. S., Gonzalez-Coloma, A., Barrero, A. F., & Quílez del Moral, J. F. (2019). Novel Insect Antifeedant and Ixodicidal Nootkatone Derivatives. Biomolecules, 9(11), 742.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/58547
dc.description.abstractNaturally occurring nootkatone, with reported insecticidal and acaricidal properties, has been used as a lead to generate molecular diversity and, consequently, new insect antifeedant and ixodicidal compounds. A total of 22 derivatives were generated by subjecting this molecule to several reactions including dehydrogenation with the iodine/DMSO system, oxidation with SeO2, epoxidation with mCPBA, oxidation or carbon homologations of the -carbonyl position with TMSOTf (trimethylsilyl trifluoromethanesulfonate) followed by Rubottom and Dess Martin periodane oxidations, condensation with formaldehyde using Yb(OTf)3 as catalyst and dehydroxilation using the Grieco protocol. The insect antifeedant (against Myzus persicae and Ropaloshysum padi) and ixodicidal (against the tick Hyalomma lusitanicum) activities of these compounds were tested. Compound 20 was the most active substance against M. persicae and R. padi, and twice more e cient than nootkatone in the antitick test.es_ES
dc.description.sponsorshipThis research was funded by Grant CTQ-2015-64049-C3-3-R / CTQ2015-64049-C3-1-R; Ministerio de Economía y Competitividad, Spain (MINECO/FEDER).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectOrganic synthesises_ES
dc.subjectNatural productses_ES
dc.subjectPesticides es_ES
dc.subjectAntitickses_ES
dc.subjectAntifeedantes_ES
dc.titleNovel Insect Antifeedant and Ixodicidal Nootkatone Derivativeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/biom9110742


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España