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dc.contributor.authorArtacho Cordón, Francisco 
dc.contributor.authorRíos Arrabal, Sandra
dc.contributor.authorLeón, J.
dc.contributor.authorFrederiksen, Hanne
dc.contributor.authorSáenz, J.M.
dc.contributor.authorMartín-Olmedo, Piedad
dc.contributor.authorFernández M. F.
dc.contributor.authorOlea Serrano, Nicolás 
dc.contributor.authorArrebola Moreno, Juan Pedro 
dc.date.accessioned2019-12-18T11:33:07Z
dc.date.available2019-12-18T11:33:07Z
dc.date.issued2019-10-11
dc.identifier.citationArtacho-Cordón, F., Ríos-Arrabal, S., León, J., Frederiksen, H., Sáenz, J. M., Martín-Olmedo, P., ... & Arrebola, J. P. (2019). Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain. Environment international, 133, 105118.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/58389
dc.description.abstractThe aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n=144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β)=1.20, p=0.060] and decreased levels of reduced glutathione (GSH) [exp(β)=0.55, p=0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β)=0.83, exp(β)=0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β)=1.73, p-value=0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79]. Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.es_ES
dc.description.sponsorshipThis research was supported in part by research grants from the European Union Commission (H2020-EJP-HBM4EU and SOE1/P1/F0082), Biomedical Research Networking Center-CIBER de Epidemiología y Salud Pública (CIBERESP), from the Institute of Health Carlos III, supported by European Regional Development Fund/FEDER (FIS-PI13/02406, FISPI14/ 00067, FIS-PI16/01820, FIS-PI16/01812, FIS-PI16/01858 and FIS-PI17/01743), and from the Consejería de Salud, Junta de Andalucía (PS-0506-2016). Funding for the equipment used was provided by Velux Fonden, Augustinus Fonden and Svend Andersen Fonden. The authors thank Kirsten og Freddy Johansens Fond and the International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC, Rigshospitalet, Copenhagen University) for economic support. Dr. Juan Pedro Arrebola is under contract within Ramón y Cajal Program (Ministerio de Economía, Industria y Competitividad de España, RYC-2016-20155).es_ES
dc.language.isoenges_ES
dc.publisherElsevier BVes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectEnvironmental phenolses_ES
dc.subjectOxidative stress es_ES
dc.subjectAdipose tissues es_ES
dc.subjectParabenses_ES
dc.titleAdipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spaines_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.envint.2019.105118


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