Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community
Metadatos
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Hernández Jérez, Antonio Francisco; Lozano Paniagua, David; González Alzaga, Beatriz; Kavvalakis, Matthaios; Tzatzarakis, Manolis; López Flores, Inmaculada; Aguilar Garduño, Clemente; Caparrós González, Rafael Arcángel; Tsatsakis, Aristidis; Lacasaña Navarro, MarinaEditorial
Elsevier BV
Materia
Pesticides DAPs Hair Urine Children Biomonitoring
Fecha
2019-07-27Referencia bibliográfica
Hernández, A. F., Lozano-Paniagua, D., González-Alzaga, B., Kavvalakis, M. P., Tzatzarakis, M. N., López-Flores, I., ... & Lacasaña, M. (2019). Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community. Environment international, 131, 104997.
Patrocinador
This study was partially funded by the Ministry of Economy, Innovation, Science and Employment, Government of Andalucia (reference number P08-CTS-04313, FEDER funds).Resumen
Levels of dialkylphosphate (DAP) metabolites were measured in hair and urine of children that lived close to
intensively farmed areas of Almeria (Southeast Spain). The levels were used as proxies for exposure of these
children to organophosphate pesticides (OPs). Determinants of exposure to DAPs were also examined. Urine and
hair samples were collected from 222 children aged 3–11 years and information on lifestyle and dietary habits
was collected from questionnaires administered to mothers. Urinary DAPs were analyzed by ultra-high performance
liquid-chromatography coupled to triple-quadrupole tandem mass-spectrometry (UHPLC-QqQ-MS/MS)
and hair DAPs by gas-chromatography coupled to mass spectrometry (GC–MS). Detection rates ranged from
21.8% for diethylphosphate (DEP) and diethylthiophosphate (DETP) to 35.9% for dimethylphosphate (DMP) in
urine; and from 42.3% for DETP to 92.8% for DMP in hair. Diethyldithiophosphate (DEDTP) was detected in
0.5% of urine samples (one child), and in 26.6% of children's hair samples. A lack of correlation was observed for
individual DAP metabolites and ΣDAPs between urine and hair samples, except for DEDTP. Urinary DAP levels of
our child population were lower than those reported for children from other countries, including NHANES
1999–2000 data.