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dc.contributor.authorCirera, Andrea
dc.contributor.authorManzanares, María Cristina
dc.contributor.authorSevilla, Pablo
dc.contributor.authorOrtiz Hernández, Mónica
dc.contributor.authorGalindo Moreno, Pablo Antonio 
dc.contributor.authorGil, Javier
dc.date.accessioned2019-11-15T09:32:45Z
dc.date.available2019-11-15T09:32:45Z
dc.date.issued2019-09-27
dc.identifier.citationCirera, A., Manzanares, M. C., Sevilla, P., Ortiz-Hernandez, M., Galindo-Moreno, P., & Gil, J. (2019). Biofunctionalization with a TGFβ-1 inhibitor peptide in the osseointegration of synthetic bone grafts: an in vivo study in beagle dogs. Materials, 12(19), 3168.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/57912
dc.description.abstractObjectives: The aim of this research was to determine the osseointegration of two presentations of biphasic calcium phosphate (BCP) biomaterial—one untreated and another submitted to biofunctionalization with a TGF- 1 inhibitor peptide, P144, on dental alveolus. The biofunctionalization of the biomaterial’s granules maintains a stable membranous bone formation throughout the experiment timeline, benefitting from the constant presence of vascular structures in the alveolar space, in a more active manner that in the control samples. Better results in the experimental groups were proven both by quantitative and qualitative analysis. Synthetic bone graft biofunctionalization results in slightly better quantitative parameters of the implant’s osseointegration. The qualitative histological and ultramicroscopic analysis shows that biofunctionalization may shorten the healing period of dental biomaterials.es_ES
dc.description.sponsorshipThe present study was supported entirely by the Research Cathedra Klockner-University of Granada.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectOsseointegrationes_ES
dc.subjectBiofunctionalizationes_ES
dc.subjectHistomorphometrical analysises_ES
dc.subjectScanning electron microscopy es_ES
dc.subjectSynthetic bone graftes_ES
dc.subjectTGFbeta- 1es_ES
dc.titleBiofunctionalization with a TGFβ-1 Inhibitor Peptide in the Osseointegration of Synthetic Bone Grafts: An In Vivo Study in Beagle Dogses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/ma12193168


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España