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dc.contributor.authorRodríguez Lara, Avilene
dc.contributor.authorMesa García, María Dolores 
dc.contributor.authorAragón Vela, Jerónimo 
dc.contributor.authorCasuso, Rafael A.
dc.contributor.authorCasals Vázquez, Cristina
dc.contributor.authorZúñiga, Jesús M.
dc.contributor.authorRodríguez Huertas, Jesús Francisco 
dc.date.accessioned2019-10-24T07:43:32Z
dc.date.available2019-10-24T07:43:32Z
dc.date.issued2019-09-06
dc.identifier.citationRodríguez-Lara, A., Mesa, M. D., Aragón-Vela, J., Casuso, R. A., Casals Vázquez, C., Zúñiga, J. M., & Huertas, J. R. (2019). Acute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extract. Nutrients, 11(9), 2133. [https://doi.org/10.3390/nu11092133]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/57483
dc.description.abstractThe objective of this study was to determine the acute (one single dose), subacute (14 days), and sub-chronic (90 days) toxicity of an aqueous virgin olive oil (VOO) extract rich in hydroxytyrosol in rats. For acute/subacute toxicity, rats were divided into three groups. The control group received distilled water (n = 9), another experimental group received a single dose of 300 mg/kg (n = 3), and a third group received one dose of 2000 mg/kg (n = 4) during 14 days. The sub-chronic study included 60rats distributed in three groups (n = 20: 10 males and 10 females) receiving daily different three doses of the VOO extract in the drinking water during 90 days: (1) 100 mg/kg, (2) 300 mg/kg, and (3) 1000 mg/kg. In parallel, a fourth additional group (n = 20: 10 males and 10 females) did not receive any extract (control group). Clinical signs, body weight, functional observations of sensory and motor reactivity, hematological and biochemical analyses, and macroscopic and microscopic histopathology were evaluated. No adverse effects were observed after the administration of the different doses of the hydroxytyrosol-rich VOO extract, which suggests that the enrichment of VOO in its phenolic compound is safe, and can be used as functional foods for the treatment of chronic degenerative diseases.es_ES
dc.description.sponsorshipThe grant #3650 managed by Fundación General Empresa-Universidad de Granada and the investigation group CTS-454 “Impacto fisiológico del estrés oxidativo, deporte, actividad física y salud” supported this studyes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectVirgin olive oiles_ES
dc.subjectHydroxytyrosoles_ES
dc.subjectAcute toxicityes_ES
dc.subjectSubacute toxicityes_ES
dc.subjectSubchronic toxicityes_ES
dc.titleAcute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extractes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu11092133


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