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dc.contributor.authorNacher Soler, German
dc.contributor.authorGarrido, Jose Manuel
dc.contributor.authorRodríguez Serrano, Fernando
dc.identifier.citationNacher-Soler, G., Garrido, J., & Rodríguez-Serrano, F. (2019). Hearing regeneration and regenerative medicine: present and future approaches. Archives of Medical Science, 15(4), 957-967es_ES
dc.description.abstractMore than 5% of the world population lives with a hearing impairment. The main factors responsible for hearing degeneration are ototoxic drugs, aging, continued exposure to excessive noise and infections. The pool of adult stem cells in the inner ear drops dramatically after birth, and therefore an endogenous cellular source for regeneration is absent. Hearing loss can emerge after the degeneration of different cochlear components, so there are multiple targets to be reached, such as hair cells (HCs), spiral ganglion neurons (SGNs), supporting cells (SCs) and ribbon synapses. Important discoveries in the hearing regeneration field have been reported regarding stem cell transplantation, migration and survival; genetic systems for cell fate monitoring; and stem cell differentiation to HCs, SGNs and SCs using adult stem cells, embryonic stem cells and induced pluripotent stem cells. Moreover, some molecular mediators that affect the establishment of functional synapses have been identified. In this review, we will focus on reporting the state of the art in the regenerative medicine field for hearing recovery. Stem cell research has enabled remarkable advances in regeneration, particularly in neuronal cells and synapses. Despite the progress achieved, there are certain issues that need a deeper development to improve the results already obtained, or to develop new approaches aiming for the clinical application.es_ES
dc.description.sponsorshipMinistry of Economy and Competitiveness (Project CTQ2014-56611-R)es_ES
dc.description.sponsorshipRegional Government of Andalusia (Project P11-CTS-7651)es_ES
dc.description.sponsorshipRamón Areces Foundation (Madrid, Spain)es_ES
dc.publisherArchives of Medical Sciencees_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 España*
dc.subjectStem cell therapyes_ES
dc.subjecthearing regenerationes_ES
dc.subjecthair celles_ES
dc.subjectspiral ganglion neurones_ES
dc.subjectribbon synapsees_ES
dc.titleHearing regeneration and regenerative medicine: present and future approacheses_ES

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Atribución-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-CompartirIgual 3.0 España