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dc.contributor.authorSalto González, Rafael 
dc.contributor.authorManzano, Manuel
dc.contributor.authorGirón González, María Dolores 
dc.contributor.authorCano, Ainara
dc.contributor.authorCastro, Azucena
dc.contributor.authorDámaso Vílchez, José
dc.contributor.authorCabrera, Elena
dc.contributor.authorLópez-Pedrosa, José María
dc.date.accessioned2019-05-18T22:31:24Z
dc.date.available2019-05-18T22:31:24Z
dc.date.issued2019-04-14
dc.identifier.citationSalto González, R. [et al.]. A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects O spring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins. Nutrients 2019, 11, 844; doi:10.3390/nu11040844.es_ES
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10481/55768
dc.description.abstractHigh-fat (HF) and rapid digestive (RD) carbohydrate diets during pregnancy promote excessive adipogenesis in o spring. This e ect can be corrected by diets with similar glycemic loads, but low rates of carbohydrate digestion. However, the e ects of these diets on metabolic programming in the livers of o spring, and the liver metabolism contributions to adipogenesis, remain to be addressed. In this study, pregnant insulin-resistant rats were fed high-fat diets with similar glycemic loads but di erent rates of carbohydrate digestion, High Fat-Rapid Digestive (HF–RD) diet or High Fat-Slow Digestive (HF–SD) diet. O spring were fed a standard diet for 10 weeks, and the impact of these diets on the metabolic and signaling pathways involved in liver fat synthesis and storage of o spring were analyzed, including liver lipidomics, glycogen and carbohydrate and lipid metabolism key enzymes and signaling pathways. Livers from animals whose mothers were fed an HF–RD diet showed higher saturated triacylglycerol deposits with lower carbon numbers and double bond contents compared with the HF–SD group. Moreover, the HF–RD group exhibited enhanced glucose transporter 2, pyruvate kinase (PK), acetyl coenzyme A carboxylase (ACC) and fatty acid (FA) synthase expression, and a decrease in pyruvate carboxylase (PyC) expression leading to an altered liver lipid profile. These parameters were normalized in the HF–SD group. The changes in lipogenic enzyme expression were parallel to changes in AktPKB phosphorylation status and nuclear expression in carbohydrate-response element and sterol regulatory element binding proteins. In conclusion, an HF–RD diet during pregnancy translates to changes in liver signaling and metabolic pathways in o spring, enhancing liver lipid storage and synthesis, and therefore non-alcoholic fatty liver disease (NAFLD) risk. These changes can be corrected by feeding an HF–SD diet during pregnancy.es_ES
dc.description.sponsorshipThis research was funded by the European Union’s Seventh Framework Programme (FP7/2007–2013): project EarlyNutrition, under grant agreement no. 289346.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectEarly programminges_ES
dc.subjectHepatic lipogenesises_ES
dc.subjectInsulin-resistant pregnancyes_ES
dc.subjectMetabolic flexibilityes_ES
dc.subjectNon-alcoholic fatty liver diseasees_ES
dc.subjectSlow digesting carbohydrateses_ES
dc.titleA Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects O spring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteinses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu11040844


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