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dc.contributor.authorMoreno Fernández, Jorge 
dc.contributor.authorDíaz Castro, Javier 
dc.contributor.authorMuñoz Alférez, María José 
dc.contributor.authorLópez Aliaga, María Inmaculada
dc.identifier.citationMoreno-Fernandez, J. [et al.]. Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats. Nutrients 2019, 11, 631; doi:10.3390/nu11030631.es_ES
dc.description.abstractAlthough dietary iron is a determinant of iron status in animals, body fat mass has been reported to have an inverse association with iron status in human studies. The goal of this study was to determine the relationship between Fe homeostasis, body composition, energy expenditure and neuroendocrine regulators for severe Fe-deficiency anaemia. Forty male Wistar albino rats recently weaned were divided at random into two groups: the control group was fed the basal diet, AIN-93G diet (normal-Fe) and the anaemic group received a low-Fe diet for 40 days. Neuroendocrine parameters that regulate basal metabolism and appetite (thyroid hormones, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon, insulin, adrenocorticotropic hormone and corticosterone), body composition, respiratory volumes, energy expenditure, haematological and biochemical were assessed. Total body fat was lower, whereas lean mass, free and total water were higher in the anemic group. O2 consumption, CO2 production, energy expenditure (EE) and respiratory quotient (RQ) were lower in the Fe-deficient animals. Triiodothyronine and thyroxine hormones decreased, while thyroid-stimulating hormone increased in the anemic group. Circulating levels of ghrelin were lower in the anemic group, while GIP, glucagon, insulin, corticosterone and adrenocorticotropic hormone levels were higher. Fe-deficiency impairs weight gain in the rats, with marked reductions in lean mass and body fat, indicating lower energy stores.es_ES
dc.description.sponsorshipThis study was supported by the Excellence Project (P11-AGR-7648) from the Regional Government of Andalusia.es_ES
dc.rightsAtribución 3.0 España*
dc.rightsAtribución 3.0 España*
dc.subjectFerropenic anaemiaes_ES
dc.subjectEndocrine regulatorses_ES
dc.subjectBody compositiones_ES
dc.subjectEnergy expenditurees_ES
dc.titleIron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Ratses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España