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dc.contributor.authorRamírez-Vélez, Robinson
dc.contributor.authorIzquierdo, Mikel
dc.contributor.authorCorrea-Bautista, Jorge Enrique
dc.contributor.authorCorrea Rodríguez, María 
dc.contributor.authorSchmidt Río Valle, Jacqueline 
dc.contributor.authorGonzález Jiménez, Emilio 
dc.contributor.authorGonzález-Jiménez, Katherine
dc.identifier.citationRamírez-Vélez, R. [et al.]. Liver Fat Content and Body Fat Distribution in Youths with Excess Adiposity. J. Clin. Med. 2018, 7, 528; doi:10.3390/jcm7120528.es_ES
dc.description.abstractThis study had two main objectives: To examine the association between body fat distribution and non-alcoholic fatty liver disease (NAFLD) and liver fat content, and to determine whether the relationship between NAFLD and regional body fat distribution, with respect to liver fat content in youths with excess adiposity, is independent of cardiorespiratory fitness (CRF) and a healthy diet. Liver fat content (controlled attenuation parameter (CAP)), body fat distribution (body mass index (BMI) z-score, waist circumference, waist-to-height ratio, fat mass/height, body fat percentage, total fat mass, android-to-gynoid fat mass ratio, visceral adipose tissue (VAT), and lean mass index, determined by dual-energy X-ray absorptiometry (DXA)), CRF (20-m shuttle-run test), and healthy diet (adherence to the Mediterranean diet by KIDMED questionnaire) were measured in 126 adolescents (66% girls) aged between 11 and 17 years. Participants were assigned to two groups according to the presence or absence of hepatic steatosis (CAP values >=225 dB/m or <225 dB/m of liver fat, respectively). Considering the similar total fat values for the two groups (>30% by DXA), youths with NAFLD had higher fat distribution parameters than those without NAFLD, regardless of sex, age, puberty stage, lean mass index, CRF, and healthy diet (p < 0.01). In the non-NAFLD group, the association between hepatic fat and fat distribution parameters presented a similar pattern, although the association was statistically insignificant after adjusting for a potential confounding variable (ps > 0.05), except for the case of VAT. Body fat distribution parameters were higher in youths with NAFLD compared to those without NAFLD. Additionally, body fat distribution showed a significant association with liver fat content as assessed by CAP in youths with NAFLD independent of CRF and adherence to the Mediterranean diet, supporting the notion that upper body fat distribution might play a pivotal role in the development of NAFLD in adolescents. These results may have implications for the clinical management of youths with excess adiposity given the high prevalence of NAFLD in children and young adults.es_ES
dc.description.sponsorshipThe HEPAFIT Study was carried out with the financial support of Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología “Francisco José de Caldas” COLCIENCIAS (contract code 59700 and no. 122277757900). K.G.-R. received a scholarship from the Universidad del Rosario, Colombia, Escuela de Medicina y Ciencias de la Salud, to do a Doctorate. R.R.-V. received funding from Convocatoria de Comité de Becas 2017, Universidad del Rosario, Colombia. M.I. is granted in part by a research grant PI17/01814 of the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). The content of this paper reflects the authors’ views alone, and the Colombian Community and COLCIENCIAS are not liable for any use that may be made of the information contained herein.es_ES
dc.rightsAtribución 3.0 España*
dc.subjectFatty liveres_ES
dc.subjectDiet es_ES
dc.subjectCardiorespiratory fitnesses_ES
dc.titleLiver Fat Content and Body Fat Distribution in Youths with Excess Adiposityes_ES

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