Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles
Metadatos
Mostrar el registro completo del ítemAutor
Díaz-García, Diana; Ardiles, Perla R.; Prashar, Sanjiv; Rodríguez Diéguez, Antonio; Páez, Paulina L.; Gómez-Ruiz, SantiagoEditorial
MDPI
Materia
Mesoporous silica nanoparticles Maleamates Copper Antibacterial ROS Oxidation reactions
Fecha
2019-01-14Referencia bibliográfica
Díaz-García, Diana; Ardiles, Perla R.; Prashar, Sanjiv; Rodríguez-Diéguez, Antonio; Páez, Paulina L.; Gómez-Ruiz, Santiago. Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles. Pharmaceutics 2019, 11, 30. [http://hdl.handle.net/10481/54885]
Patrocinador
This research was funded by Ministerio de Ciencia, Innovación y Universidades Spain-FEDER, grants number CTQ2015-66164-R and CTQ2017-90802-REDT and by Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) (PICT 2015 Nº1558).Resumen
Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with
potential applications in different therapeutic areas and that have been extensively used as drug
carriers in different fields of medicine. The present work is focused on the synthesis of MSNs
containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions
(MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The
Cu-containing nanomaterials have been characterized by different techniques and the preliminary
antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two
types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum
inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological
results showed a moderate antibacterial activity against Escherichia coli which motivated a more
detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing
nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the
prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of
benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity
of the materials and the observed oxidative stress in bacteria. This may help in the future, for
a more accurate rational design of antibacterial nanosystems, based on their observed catalytic
oxidation activity.