AHL-lactonase expression in three marine emerging pathogenic Vibrio spp. reduces virulence and mortality in brine shrimp (Artemia salina) and Manila clam (Venerupis philippinarum)
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Torres Béjar, Marta; Reina, José Carlos; Fuentes-Monteverde, Juan Carlos; Fernández, Gerardo; Rodríguez, Jaime; Jiménez, Carlos; Llamas Company, InmaculadaEditorial
Public Library of Science (PLOS)
Fecha
2018-04-17Referencia bibliográfica
Torres M, Reina JC, Fuentes-Monteverde JC, Fernández G, Rodríguez J, Jiménez C, et al. (2018) AHL-lactonase expression in three marine emerging pathogenic Vibrio spp. reduces virulence and mortality in brine shrimp (Artemia salina) and Manila clam (Venerupis philippinarum). PLoS ONE 13(4): e0195176 [http://hdl.handle.net/10481/53230]
Patrocinador
This research was supported in part by grants from the Ministerio de Economía y Competitividad (Spain) (http://www.mineco.gob. es/portal/site/mineco/idi) (AGL2012-39274-C02- 02; AGL2015-68806-R; AGL2015-63740-C2-2-R). José Carlos Reina is supported by a FPU fellowship rom the Ministerio de Educación, Cultura y Deporte (Spain) (https://www.mecd.gob.es/ portada-mecd/) (FPU15-01717) and a Initiation to Research fellowship for Master Students (2016) from the University of Granada (Spain)Resumen
Bacterial infectious diseases produced by Vibrio are the main cause of economic losses in
aquaculture. During recent years it has been shown that the expression of virulence genes
in some Vibrio species is controlled by a population-density dependent gene-expression
mechanism known as quorum sensing (QS), which is mediated by the diffusion of signal
molecules such as N-acylhomoserine lactones (AHLs). QS disruption, especially the enzymatic
degradation of signalling molecules, known as quorum quenching (QQ), is one of the
novel therapeutic strategies for the treatment of bacterial infections. In this study, we present
the detection of AHLs in 34 marine Vibrionaceae strains. Three aquaculture-related pathogenic
Vibrio strains, V. mediterranei VibC-Oc-097, V. owensii VibC-Oc-106 and V. coralliilyticus
VibC-Oc-193 were selected for further studies based on their virulence and high
production of AHLs. This is the first report where the signal molecules have been characterized
in these emerging marine pathogens and correlated to the expression of virulence factors.
Moreover, the results of AHL inactivation in the three selected strains have been
confirmed in vivo against brine shrimps (Artemia salina) and Manila clams (Venerupis philippinarum).
This research contributes to the development of future therapies based on AHL
disruption, the most promising alternatives for fighting infectious diseases in aquaculture.