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dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorToledano Osorio, Manuel 
dc.contributor.authorGuerado, Enrique
dc.contributor.authorCaso, Enrique
dc.contributor.authorOsorio Ruiz, María Estrella 
dc.contributor.authorOsorio Ruiz, Raquel
dc.identifier.citationToledano M, Toledano-Osorio M, Guerado E, Caso E, Osorio E, Osorio R. Assessing bone quality through mechanical properties in postmenopausal trabecular bone. Injury. 2018 Sep;49 Suppl 2:S3-S10. doi: 10.1016/j.injury.2018.07.035.es_ES
dc.description.abstractBackground: The inner structure of trabecular bone is a result of structural optimisation provided by remodeling processes. Changes in hormonal status related to menopause cause bone tissue loss and micro-architectural deterioration with a consequent susceptibility to fracture. Accumulation of micro-damage in bone, as a function of the rate of production and rate of repair, underlies the development of stress fractures, increasing fragility associated to age and osteoporosis, especially in transmenopausal women. Patients and Methods: Quasi-static and nano-dynamic mechanical characterisation were undertaken in trabecular bone from femoral neck biopsies of postmenopausal women. AFM complementary studies were performed to determine nano-roughness (SRa) and the fibrils width of collagen. Nanoindentations were used to quantify transmenopausal changes in intrinsic mechanical properties of trabecular bone: hardness (Hi), modulus of Young (Ei), complex modulus (E*), tan delta (δ), storage modulus (E') and loss modulus (E"). Results: As result of the quasi-static measurements, 0.149 (0.036) GPa and 2.95 (0.73) GPa of Hi and Ei were obtained, respectively. As result of the nano-dynamic measurements, 17.94 (3.15), 0.62 (0.10), 13.79 (3.21 and 6.39 (1.28) GPa of E*, tan (δ), E' and E" were achieved, respectively. 101.07 SRa and 831.28 nm of fibrils width were additionally obtained. Conclusion: This study poses a first approach to the measurement of bone quality in postmenopausal trabecular bone by combining quasistatic, nano-DMA analysis and tribology of dentin surface through AFM characterizationes_ES
dc.description.sponsorshipProject MAT2017-85999-P supported by the Ministry of Economy and Competitiveness (MINECO) and European Regional Development Fund (FEDER).es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectTrabecular bonees_ES
dc.titleAssessing bone quality through mechanical properties in postmenopausal trabecular bone.es_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España