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The role of protein dynamics in loss-of-function disease mechanisms: a NQO1 cancer-associated polymorphism as model

dc.contributor.advisorPey Rodríguez, Ángel Luis 
dc.contributor.authorMedina Carmona, Encarnación 
dc.contributor.otherUniversidad de Granada.es_ES
dc.date.accessioned2018-07-19T11:05:16Z
dc.date.available2018-07-19T11:05:16Z
dc.date.issued2018
dc.identifier.citationMedina Carmona, Encarnación. The role of protein dynamics in loss-of-function disease mechanisms: a NQO1 cancer-associated polymorphism as model. Granada: Universidad de Granada, 2018. [http://hdl.handle.net/10481/52374]es_ES
dc.identifier.isbn9788491639176
dc.identifier.urihttp://hdl.handle.net/10481/52374
dc.description.sponsorshipTesis Univ. Granada.es_ES
dc.description.sponsorshipPrograma Oficial de Doctorado en Químicaes_ES
dc.description.sponsorshipWe thank Prof. José Manuel Sánchez-Ruíz for kindly providing the home-built software to determine solvent accessible surface areas. This work was supported by grants from MINECO (BIO2012-34937, CSD2009-00088 and SAF2011-23933), Junta de Andalucia (P11-CTS-07187), European Union (FP7-REGPOT-CT2012-31637- IMBRAIN) and FEDER Funds. A.L.P. is supported by a Ramón y Cajal research contract from MINECO/ University of Granada (RYC-2009-04147). N.M.-T. is supported by FPI predoctoral fellowships from MINECO. E.M.-C. is supported by a predoctoral contract from Junta de Andalucia.es_ES
dc.description.sponsorshipALP thanks Prof. Jose Manuel Sanchez-Ruiz for support. This work was supported by grants from MINECO (BIO2015 66426-R to JMSR, CTQ2015-64445-R to JLN and SAF2015-69796 to ES), Junta de Andalucia (P11- CTS-07187 to ALP) and FEDER funds. EMC acknowledges a pre-doctoral fellowship from Junta de Andalucia.es_ES
dc.description.sponsorshipALP thanks Prof. Jose Manuel Sanchez-Ruiz for support. JLN thanks C. Arrowsmith for the kind gift of the SAMp73 vector. We acknowledge the ESRF for the provision of synchrotron radiation time at beam lines ID29 and ID30A-1, and the staff for their helpful support. EMC acknowledges a pre-doctoral fellow- ship from Junta de Andalucía.es_ES
dc.description.sponsorshipALP thanks Prof Jose Manuel Sánchez-Ruiz and BM thanks Prof Francisco Conejero-Lara for support. This work was supported by the Spanish Ministry of Economy and Competitiveness (BIO2015-66426-R to JMSR and BIO2013-40697-R to FCL), Junta de Andalucía (P11-CTS-07187toALP) and FEDER funds. EMC acknowledges a predoctoral fellowship from Junta de Andalucía. We acknowledge the Diamond Light Source for provision of synchrotron radiation time at beam line B21, and to Robert Rambo and Nathan Cowieson for assistance during data collection. The sponsors had no role in the design of this study.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenges_ES
dc.publisherUniversidad de Granadaes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/31637
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectQuímica es_ES
dc.subjectProteínaes_ES
dc.subjectEnfermedades_ES
dc.subjectCáncer es_ES
dc.titleThe role of protein dynamics in loss-of-function disease mechanisms: a NQO1 cancer-associated polymorphism as modeles_ES
dc.typedoctoral thesises_ES
dc.subject.udc543es_ES
dc.subject.udc616es_ES
dc.subject.udc2300es_ES
dc.subject.udc2301es_ES
europeana.typeTEXTen_US
europeana.dataProviderUniversidad de Granada. España.es_ES
europeana.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.rights.accessRightsopen accessen_US


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