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dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorPérez-Álvarez, Mayra C.
dc.contributor.authorSánchez Aguilera, Fátima 
dc.contributor.authorOsorio Ruiz, María Estrella 
dc.contributor.authorCabello Malagón, Inmaculada
dc.contributor.authorToledano Osorio, Manuel 
dc.contributor.authorOsorio Ruiz, Raquel 
dc.date.accessioned2018-04-16T09:14:48Z
dc.date.available2018-04-16T09:14:48Z
dc.date.issued2017-12
dc.identifier.citationToledano M, Pérez-Álvarez MC, Aguilera FS, Osorio E, Cabello I, Toledano-Osorio M, Osorio R. A zinc oxide-modified hydroxyapatite-based cement facilitated new crystalline-stoichiometric and amorphous apatite precipitation on dentine. Int Endod J. 2017 Dec;50 Suppl 2:e109-e119.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/50238
dc.description.abstractAim: To evaluate the remineralization ability of two dentin canal sealer cements. Methodology: Dentin surfaces were subjected to: i) 37% phosphoric acid (PA) or ii) 0.5 M ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite-based cements, containing sodium hydroxide (calcypatite) or zinc oxide (oxipatite), respectively. Samples were stored in simulated body fluid during 24 h or 21 d. Remineralization of the dentin surfaces were studied by Raman spectroscopy, mapping with K-means cluster and hierarchical cluster analysis were done. Nano-roughness and collagen fibrils width measurements were performed by means of an atomic force microscopy. Results: PA+oxipatite promoted both the highest dentin mineralization and crystallographic maturity at the dentin surface. Non-crystalline amorphous-like apatites were also formed. Dentin treated with PA+calcypatite attained the roughest surface with minimal fibril width. Crosslinking of collagen only raised in the group PA+oxipatite, after 21 d. The maximum relative mineral concentration and structure of collagen referred to amide I and ratio amide III/AGEs was achieved after using PA+calcypatite at 21 d time point. EDTA produced a lower stoichiometric hydroxyapatite with decreased maturity, at the expense of the carbonate band widening, though it favored the nucleation of carbonated calcium phosphate. Conclusions: Surfaces treated with PA+oxipatite attained the highest dentin remineralization with both crystalline-stoichiometric and amorphous apatites, at long term. EDTA conditioning facilitated amorphous-bulk mineral precipitation. This amorphization, more intense after using oxipatite, provided an ion-rich environment favoring in situ dentin remineralization.es_ES
dc.description.sponsorshipThis work was supported by the Ministry of Economy and Competitiveness (MINECO) [Project MAT2014-52036-P] and European Regional Development Fund (FEDER).es_ES
dc.language.isoenges_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectRamanes_ES
dc.subjectcrystallinityes_ES
dc.subjectdentinees_ES
dc.subjecthydroxyapatitees_ES
dc.subjectremineralizationes_ES
dc.subjectzinces_ES
dc.titleA zinc oxide-modified hydroxyapatite-based cement facilitated new crystalline-stoichiometric and amorphous apatite precipitation on dentine.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1111/iej.12807


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