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dc.contributor.advisorAbadía Molina, Francisco es_ES
dc.contributor.authorMorón Calvente, Virginiaes_ES
dc.contributor.otherUniversidad de Granada. Departamento de Biología Celulares_ES
dc.date.accessioned2018-02-09T09:16:44Z
dc.date.available2018-02-09T09:16:44Z
dc.date.issued2018
dc.date.submitted2017-10-30
dc.identifier.citationMorón Calvente, V. Inhibitor of apoptosis proteins (IAPs) expression in monocyte to macrophage differentiation and M1/M2 polarization. Granada: Universidad de Granada, 2018. [http://hdl.handle.net/10481/49413]es_ES
dc.identifier.isbn9788491637615
dc.identifier.urihttp://hdl.handle.net/10481/49413
dc.description.abstractMonocytes and macrophages constitute the first line of defense of the immune system against external pathogens and fulfill other essential roles in tissue homeostasis. The ability of monocytes to differentiate into macrophages constitutes an important asset in inflammatory situations because it allows for the quick recruitment of immune cells from the bloodstream to the site of infection. Furthermore, macrophages are highly plastic and can respond differently to changes in their environment and acquire a more cytotoxic and pro-inflammatory phenotype (M1) or a more healing and anti-inflammatory one (M2) and perform different roles during inflammation and resolution of inflammation. This polarization capacity enables the innate immune system to quickly respond to threatening situations faster than tissue specific differentiation or adaptive immune responses. Both processes, differentiation and polarization of macrophages, are important in inflammation resolution and their deregulation promotes the development of several pathologies, including cancer. On the other hand, macrophage activation syndrome (MAS), is a life-threatening complication of some rheumatic diseases, it is caused by an excessive activation and expansion of macrophages and T-lymphocytes. The inhibitor of apoptosis protein family (IAPs) has important roles in the regulation of several cellular processes and in innate and adaptive immune responses, specifically in many macrophage functions and almost every signaling pathway leading to NF-κB activation, which is implicated in pro-inflammatory cytokine production. In this thesis we wanted to characterize the expression profile of IAPs in the differentiation of monocytes to macrophages and in polarization into M1/M2 states, study the effect of IAPs pharmacological inhibition in macrophage differentiation and polarization and analyze the possibility of IAPs targeting as a therapeutic approach for macro- phage activation syndrome.en
dc.description.abstractEn esta tesis queríamos evaluar la implicación de las proteínas inhibidoras de la apoptosis (IAPs, en inglés) en la diferenciación y polarización de macrófagos y estudiar la posibilidad de usar los IAPs como dianas terapéuticas en el tratamiento del síndrome de activación macrofágica.es
dc.description.sponsorshipTesis Univ. Granada. Programa Oficial de Doctorado en Biomedicinaes_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenges_ES
dc.publisherUniversidad de Granadaes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subjectSistema inmunológicoes_ES
dc.subjectApoptosises_ES
dc.subjectMacrófagos es_ES
dc.subjectExpresión génicaes_ES
dc.subjectFenotipoes_ES
dc.subjectTerapéutica es_ES
dc.titleInhibitor of apoptosis proteins (IAPs) expression in monocyte to macrophage differentiation and M1/M2 polarizationen_EN
dc.typedoctoral thesises_ES
dc.subject.udc61es_ES
dc.subject.udc543.384es_ES
dc.subject.udc2301091es_ES
europeana.typeTEXTen_US
europeana.dataProviderUniversidad de Granada. España.es_ES
europeana.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.rights.accessRightsopen accessen_US


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