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Mitochondrial ferritin deficiency reduces male fertility in mice
dc.contributor.author | Maccarinelli, Federica | es_ES |
dc.contributor.author | Regoni, Maria | es_ES |
dc.contributor.author | Carmona Rodríguez-Acosta, Fernando | es_ES |
dc.contributor.author | Poli, Maura | es_ES |
dc.contributor.author | Meyron-Holtz, Esther G. | es_ES |
dc.contributor.author | Arosio, Paolo | es_ES |
dc.date.accessioned | 2017-07-21T11:59:42Z | |
dc.date.available | 2017-07-21T11:59:42Z | |
dc.date.issued | 2017-01-09 | |
dc.identifier.citation | Maccarinelli, F.; et al. Mitochondrial ferritin deficiency reduces male fertility in mice. Reproduction, Fertility and Development: online (2017). [http://hdl.handle.net/10481/47233] | es_ES |
dc.identifier.issn | 1031-3613 | |
dc.identifier.issn | 1448-5990 | |
dc.identifier.uri | http://hdl.handle.net/10481/47233 | |
dc.description.abstract | Mitochondrial ferritin (FtMt) is a functional ferritin targeted to mitochondria that is highly expressed in the testis. To investigate the role of FtMt in the testis we set up a series of controlled matings between FtMt gene-deletion mice (FtMt–/–) with FtMt+/+ mice. We found that the number of newborns per litter and the fertility rate were strongly reduced for the FtMt–/– males, but not for the females, indicating that FtMt has an important role for male fertility. The morphology of the testis and of the spermatozoa of FtMt–/– mice was normal and we did not detect alterations in sperm parameters or in oxidative stress indices. In contrast, we observed that the cauda epididymides of FtMt–/– mice were significantly lighter and contained a lower number of spermatozoa compared with the controls. Also, the ATP content of FtMt–/– spermatozoa was found to be lower than that of FtMt+/+ spermatozoa. These data show that FtMt contributes to sperm epididymis maturation and to male fertility. | en_EN |
dc.description.sponsorship | The work was partially supported by MIUR grant PRIN10–11 to P. A. and by Telethon grant GGP1099 to P. A. | en_EN |
dc.language.iso | eng | es_ES |
dc.publisher | CSIRO Publishing | es_ES |
dc.subject | ATP | en_EN |
dc.subject | Spermatogenesis | en_EN |
dc.subject | Ferritin | en_EN |
dc.subject | Mitochondrial ferritin | en_EN |
dc.subject | Sperm motility | en_EN |
dc.title | Mitochondrial ferritin deficiency reduces male fertility in mice | en_EN |
dc.type | journal article | en_EN |
dc.rights.accessRights | open access | en_EN |
dc.identifier.doi | 10.1071/RD16348 |