Protein crystallization in short-peptide supramolecular hydrogels: A versatile strategy towards biotechnological composite materials
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AuthorConejero-Muriel, Mayte; Contreras-Montoya, Rafael; Álvarez Cienfuegos Rodríguez, Luis; Gavira Gallardo, José Antonio
Royal Society of Chemistry
CrystallizationColloidsProtein crystalsBiotechnologyDrugsPeptidesSupramomolecular chemistryComposite materials
Conejero-Muriel, M.; et al. Protein crystallization in short-peptide supramolecular hydrogels: A versatile strategy towards biotechnological composite materials. CrystEngComm,17: 8072-8078 (2015). [http://hdl.handle.net/10481/43528]
SponsorshipThis research was funded by the MICINN (Spain) projects BIO2010-6800 (JAG), CTQ2012-34778 (JJDM), and “Factoría Española de Cristalización” Consolider-Ingenio 2010 (JAG & MCM), and by Junta de Andalucía (Spain) project P12-FQM- 2721 (LAC). EDRF funds JAG, LAC & JMC. JJDM thanks MICINN for a Ramon y Cajal Fellowship and MCM thanks CSIC for her JAE Fellowship
Protein crystallization in hydrogels has been explored with the main purpose of facilitating the growth of high quality crystals while increasing their size to enhance their manipulation. New avenues are currently being built for the use of protein crystals as source materials to create sensors and drug delivery vehicles, to name just a few. In this sense, short-peptide supramolecular hydrogels may play a crucial role in integrating protein crystals within a wider range of applications. In this article, we show that protein crystallization in short-peptide supramolecular hydrogels is feasible and independent of the type of peptide that forms the hydrogel and/or the protein, although the output is not always the same. As a general trend, it is confirmed that hydrogel fibers are always incorporated within crystals so that novel composite materials for biotechnological applications with enhanced properties are produced.