Biologic Agents for Periodontal Regeneration and Implant Site Development

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URI: http://hdl.handle.net/10481/39133
ISSN: 2314-6133
ISSN: 2314-6141
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Author
Suárez-López del Amo, Fernando; Monje, Alberto; Padial Molina, Miguel; Tang, ZhiHui; Wang, Hom-Lay
Editorial
Hindawi Publishing Corporation
Materia
Periodontal
 
Implant Site
 
Bone
 
Regeneration
 
Treatment
 
Augmentation
 
Date
2015
Referencia bibliográfica
Suárez-López del Amo, F.; et al. Biologic Agents for Periodontal Regeneration and Implant Site Development. Biomed Research International, 2015: 957518 (2015). [http://hdl.handle.net/10481/39133]
Sponsorship
This paper was partially supported by the University of Michigan Periodontal Graduate Student Research Fund.
Abstract
The advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and investigated. Different growth factors trigger different reactions in the tissues of the periodontium at various cellular levels. Proliferation, migration, and differentiation constitute the main target areas of these molecular mediators. It was the purpose of this comprehensive review to describe the origin and rationale, evidence, and the most current understanding of the following biologic agents: Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB), Enamel Matrix Derivate (EMD), Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2), Bone Morphogenic Proteins (BMPs, BMP-2 and BMP-7), Teriparatide PTH, and Growth Differential Factor-5 (GDF-5).
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