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dc.contributor.authorSauro, Salvatore
dc.contributor.authorOsorio Ruiz, Raquel 
dc.contributor.authorWatson, Timothy F.
dc.contributor.authorToledano Pérez, Manuel
dc.identifier.citationSauro, S.; Osorio Ruiz, R.; Watson, T.F.; Toledano Pérez, M. Influence of phosphoproteins' biomimetic analogs on remineralization of mineral-depleted resin-dentin interfaces created with ion-releasing resin-based systems. Dental Materials, 31(7): 759-777 (2015). []es_ES
dc.description.abstractObjectives. The study aimed at evaluating the remineralization of acid-etched dentin pre-treated with primers containing biomimetic analogues and bonded using an ion-releasing Ca-Silicate/CaP light-curable resin-based material.es_ES
dc.description.abstractMethods. An experimental etch-and-rinse adhesive system filled with Ca++, PO4-3-relesing micro-fillers was created along with two experimental primers containing biomimetic analogues such as sodium trimetaphosphate (TMP) and/or polyaspartic acid (PLA). Dentin specimens etched with 37% H3PO4 were pre-treated with two aqueous primers containing the polyanionic biomimetic analogues or deionized water and subsequently bonded using the experimental resin-based materials. The specimens were sectioned and analyzed by AFM/nanoindentation to evaluate changes in the modulus of elasticity (Ei) across the resin-dentin interface at different AS storage periods (up to 90 days). Raman cluster analysis was also performed to evaluate the chemical changes along the interface. The phosphate uptake by the acid-etched dentin was evaluated using the ATR-FTIR. Additional resin–dentin specimens were tested for microtensile bond strength. SEM examination was performed after de-bonding, while confocal laser microscopy was used to evaluate the interfaces ultramorphology and micropermeability.es_ES
dc.description.abstractResults. Both biomimetic primers induced phosphate uptake by acid-etched dentin. Specimens created with the ion-releasing resin in combination with the pre-treatment primers containing either PLA and TMA showed the greatest recovery of the Ei of the hybrid layer, with no decrease in μTBS (P>0.05) after 3-month AS storage. The ion-releasing resin applied after use of the biomimetic primers showed the greatest reduction in micropermeability due to mineral precipitation; these results were confirmed using SEM.es_ES
dc.description.abstractSignificance. The use of Ca-Silicate/CaP ion-releasing resin-based system applied to acid-etched dentin pre-treated with biomimetic primers containing analogues of phosphoproteins such as poly-L-aspartic acid and/or sodium trimetaphosphate, provide a suitable bonding approach for biomimetic remineralization of resin-dentin interfaces.es_ES
dc.description.sponsorshipThis work was supported by grant MINECO/FEDER MAT2011-24551 and MINECO/FEDER MAT2014-52036-P.es_ES
dc.publisherAcademy of Dental Materialses_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 License
dc.subjectResin-based systemses_ES
dc.titleInfluence of phosphoproteins’ biomimetic analogues on remineralization of mineral-depleted resin-dentin interfaces created with ion-releasing resin-based systemses_ES

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