Show simple item record

dc.contributor.authorLópez López, Modesto Torcuato es
dc.contributor.authorScionti, Giuseppees
dc.contributor.authorOliveira, Ana C.es
dc.contributor.authorGarcía López-Durán, Juan De Dios es
dc.contributor.authorMuñoz Campos, Antonioes
dc.contributor.authorAlaminos Mingorance, Miguel es
dc.contributor.authorRodríguez, Ismael Ángeles
dc.date.accessioned2015-09-25T11:16:17Z
dc.date.available2015-09-25T11:16:17Z
dc.date.issued2015-07-24
dc.identifier.citationLópez-López, M.T.; et al. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. Plos One, 10(7): e0133878 (2015). [http://hdl.handle.net/10481/37665]es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10481/37665
dc.description.abstractWe report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces. This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.es_ES
dc.description.sponsorshipThis work was supported by FIS2013-41821-R (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (co-funded by FEDER funds, EU) to MTLL, GS, JDGD and IAR; FIS PI14/0955 (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III-co-funded by FEDER funds, EU) to AC and MA; FIS PI14/1343 (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III -co-funded by FEDER funds, EU) to AC and MA; PI11/01582 (http://www.mineco.gob.es/): Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III -co-funded by FEDER funds, EU) to AC and MA; and P10-CTS-6060 (http://www.juntadeandalucia.es/organismo​s/economiainnovacioncienciayempleo.html) Junta de Andalucía, Spain (Consejería de Innovación, Ciencia y Empleo—Proyectos de Excelencia) to AC and MA.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS)es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectMagnetic field-responsivees_ES
dc.subjectBiomaterialses_ES
dc.subjectNanoparticleses_ES
dc.subjectMechanical propertieses_ES
dc.subjectDeformationes_ES
dc.subjectPolymers es_ES
dc.subjectTissue mechanicses_ES
dc.subjectFibrines_ES
dc.titleGeneration and Characterization of Novel Magnetic Field-Responsive Biomaterialses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1371/journal.pone.0133878


Files in this item

[PDF]

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License