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dc.contributor.authorSoto-Méndez, María José
dc.contributor.authorRomero-Abal, María Eugenia
dc.contributor.authorAguilera García, María Eugenia
dc.contributor.authorCruz Rico, María
dc.contributor.authorSolomons, Noel W.
dc.contributor.authorSchümann, Klaus
dc.contributor.authorGil Hernández, Ángel 
dc.date.accessioned2015-09-04T09:30:12Z
dc.date.available2015-09-04T09:30:12Z
dc.date.issued2015
dc.identifier.citationSoto-Méndez, M.J.; et al. Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala. Plos One, 10(6): e0129158 (2015). []es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10481/37252
dc.description.abstractBackground: Undernutrition and inflammation are related in many ways; for instance, non-hygienic environments are associated with both poor growth and immunostimulation in children.es_ES
dc.description.abstractObjective: To describe any existing interaction among different inflammation biomarkers measured in the distinct anatomical compartments of whole blood, feces, plasma and saliva.es_ES
dc.description.abstractMethods: In this descriptive, cross-sectional study, samples of whole blood, feces, plasma and saliva were collected on the 8th and last week of observation among 87 attendees (42 girls and 45 boys) of 3 daycare centers offering a common 40-day rotating menu in Guatemala’s Western Highlands. Analyses included white blood cell count (WBC), fecal calprotectin, and plasmatic and salivary cytokines including IL-1B, IL-6, IL-8, IL-10 and TNF-α. Associations were assessed using Spearman rank-order and goodness-of-fit correlations, as indicated, followed by backwards-elimination multiple regression analyses to determine predictor variables for IL-10 in both anatomical compartments.es_ES
dc.description.abstractResults: Of a total of 66 cross-tabulations in the Spearman hemi-matrix, 22 (33%) were significantly associated. All 10 paired associations among the salivary cytokines had a significant r value, whereas 7 of 10 possible associations among plasma cytokines were significant. Associations across anatomical compartments, however, were rarely significant. IL-10 in both biological fluids were higher than corresponding reference values. When a multiple regression model was run in order to determine independent predictors for IL-10 in each anatomical compartment separately, IL-6, IL-8 and TNF-α emerged as predictors in plasma (r2 = 0.514) and IL-1B, IL-8 and TNF-α remained as independent predictors in saliva (r2 = 0.762). Significant cross-interactions were seen with WBC, but not with fecal calprotectin.es_ES
dc.description.abstractConclusion: Interactions ranged from robust within the same anatomical compartment to limited to nil across distinct anatomical compartments. The prominence of the anti-inflammatory cytokine, IL-10, in both plasma and saliva is consistent with its counter-regulatory role facing a broad front of elevated pro-inflammatory cytokines in the same compartment.es_ES
dc.description.sponsorshipStudies were funded by the Hildegard Grunow Foundation, Munich, Germany and the Department of Biochemistry and Molecular Biology II from Granada University, Granada, Spain.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS)es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectCytokines es_ES
dc.subjectBlood plasma es_ES
dc.subjectBiomarkerses_ES
dc.subjectSaliva es_ES
dc.subjectInflammation es_ES
dc.subjectChildrenes_ES
dc.subjectWhite blook cellses_ES
dc.subjectCell enumeration techniqueses_ES
dc.titleAssociations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemalaes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1371/journal.pone.0129158


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