Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment

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URI: http://hdl.handle.net/10481/37238
ISSN: 0022-1333
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Author
Henríquez-Hernández, Luis Alberto; Valenciano, Almudena; Foro-Arnalot, Palmira; Álvarez Cubero, María Jesús; Cózar Olmo, José Manuel; Suárez-Novo, José Francisco; Castells-Esteve, Manel; Fernández-Gonzalo, Pablo; De-Paula-Carranza, Belén; Ferrer, Montse; Guedea, Ferrán; Sancho-Pardo, Gemma; Craven-Bartle, Jordi; Ortiz-Gordillo, María José; Cabrera-Roldán, Patricia; Herrera-Ramos, Estefanía; Rodríguez-Gallego, Carlos; Lara, Pedro C.
Editorial
Indian Academy of Sciences
Materia
5-alpha-reductase polymorphism
 
5-alpha-reductase inhibitors
 
OpenArray
 
Prostate cancer
 
Pharmacoethnicity
 
Date
2015
Referencia bibliográfica
Henríquez-Hernández, L.A.; et al. Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment. Journal of Genetics, 94(2): 335-341 (2015). [http://hdl.handle.net/10481/37238]
Sponsorship
This work was subsidized by the grant from the Instituto de Salud Carlos III (Ministerio de Economía y Competitividad from Spain), ID: PI12/01867. Almudena Valenciano has a grant from the Instituto Canario de Investigación del Cáncer (ICIC).
Abstract
We designed a study aimed to evaluate the genotypic distribution of 22 SNPs in SRD5A1 and SRD5A2 in a set of Spanish prostate cancer patients, to determine the homogeneity of the population and to disclose potential bias associated with the failure of 5α-RI when prescribed.
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