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dc.contributor.authorMapelli, Lisa
dc.contributor.authorPagani, Martina
dc.contributor.authorGarrido Alcázar, Jesús Alberto 
dc.contributor.authorD'Angelo, Egidio
dc.date.accessioned2015-06-15T12:24:04Z
dc.date.available2015-06-15T12:24:04Z
dc.date.issued2015
dc.identifier.citationMapelli, L.; et al. Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit. Frontiers in Cellular Neuroscience, 9: 169 (2015). [http://hdl.handle.net/10481/36629]es_ES
dc.identifier.other25999817
dc.identifier.urihttp://hdl.handle.net/10481/36629
dc.description.abstractThe way long-term potentiation (LTP) and depression (LTD) are integrated within the different synapses of brain neuronal circuits is poorly understood. In order to progress beyond the identification of specific molecular mechanisms, a system in which multiple forms of plasticity can be correlated with large-scale neural processing is required. In this paper we take as an example the cerebellar network, in which extensive investigations have revealed LTP and LTD at several excitatory and inhibitory synapses. Cerebellar LTP and LTD occur in all three main cerebellar subcircuits (granular layer, molecular layer, deep cerebellar nuclei) and correspondingly regulate the function of their three main neurons: granule cells (GrCs), Purkinje cells (PCs) and deep cerebellar nuclear (DCN) cells. All these neurons, in addition to be excited, are reached by feed-forward and feed-back inhibitory connections, in which LTP and LTD may either operate synergistically or homeostatically in order to control information flow through the circuit. Although the investigation of individual synaptic plasticities in vitro is essential to prove their existence and mechanisms, it is insufficient to generate a coherent view of their impact on network functioning in vivo. Recent computational models and cell-specific genetic mutations in mice are shedding light on how plasticity at multiple excitatory and inhibitory synapses might regulate neuronal activities in the cerebellar circuit and contribute to learning and memory and behavioral control.es_ES
dc.description.sponsorshipThis work was supported by European Union grants to ED [CEREBNETFP7-ITN238686, REAL NET FP7-ICT270434, Human Brain Project(HBP-604102)] and by Centro Fermi grant [13(14)] to LM.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Foundationes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/270434es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectCerebellumes_ES
dc.subjectInhibitory synapsees_ES
dc.subjectExcitatory synapsees_ES
dc.subjectLTP (Long-term potentiation)es_ES
dc.subjectLTD (Long-term depression)es_ES
dc.titleIntegrated plasticity at inhibitory and excitatory synapses in the cerebellar circuites_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3389/fncel.2015.00169
dc.identifier.doi1662-5102


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