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dc.contributor.authorCabeza Montilla, Laura 
dc.contributor.authorOrtiz Quesada, Raúl 
dc.contributor.authorArias Mediano, José Luis 
dc.contributor.authorRuiz Martínez, Adolfina 
dc.contributor.authorEntrena Fernández, José Manuel 
dc.contributor.authorLuque Caro, Raquel
dc.contributor.authorMelguizo Alonso, Consolación 
dc.date.accessioned2015-04-30T11:20:29Z
dc.date.available2015-04-30T11:20:29Z
dc.date.issued2015
dc.identifier.citationCabeza, L.; et al. Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles. International Journal of Nanomedicine, 10: 1291-1306 (2015). []es_ES
dc.identifier.issn1178-2013
dc.identifier.urihttp://hdl.handle.net/10481/35851
dc.description.abstractThe use of doxorubicin (DOX), one of the most effective antitumor molecules in the treatment of metastatic breast cancer, is limited by its low tumor selectivity and its severe side effects. Colloidal carriers based on biodegradable poly(butylcyanoacrylate) nanoparticles (PBCA NPs) may enhance DOX antitumor activity against breast cancer cells, thus allowing a reduction of the effective dose required for antitumor activity and consequently the level of associated toxicity. DOX loading onto PBCA NPs was investigated in this work via both drug entrapment and surface adsorption. Cytotoxicity assays with DOX-loaded NPs were performed in vitro using breast tumor cell lines (MCF-7 human and E0771 mouse cancer cells), and in vivo evaluating antitumor activity in immunocompetent C57BL/6 mice. The entrapment method yielded greater drug loading values and a controlled drug release profile. Neither in vitro nor in vivo cytotoxicity was observed for blank NPs. The 50% inhibitory concentration (IC50) of DOX-loaded PBCA NPs was significantly lower for MCF-7 and E0771 cancer cells (4 and 15 times, respectively) compared with free DOX. Furthermore, DOX-loaded PBCA NPs produced a tumor growth inhibition that was 40% greater than that observed with free DOX, thus reducing DOX toxicity during treatment. These results suggest that DOX-loaded PBCA NPs have great potential for improving the efficacy of DOX therapy against advanced breast cancers.es_ES
dc.description.sponsorshipThis investigation was funded by FEDER, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III (FIS) through projects Nos PI11/01862 and PI11/02571, and by the Consejería de Salud de la Junta de Andalucía through project No PI-0338. The authors wish to express their gratitude to G Ortiz Ferron (CIC, University of Granada, Spain) for his skillful assistance with cytometry experiments.es_ES
dc.language.isoenges_ES
dc.publisherDove Presses_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectBiodegradable polymeres_ES
dc.subjectCarcinomaes_ES
dc.subjectCytotoxicityes_ES
dc.subjectChemotherapeutic druges_ES
dc.subjectDrug deliveryes_ES
dc.subjectNanopolymeres_ES
dc.titleEnhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticleses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.2147/IJN.S74378


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