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dc.contributor.authorGiampieri, Francescaes_ES
dc.contributor.authorÁlvarez-Suárez, José M.es_ES
dc.contributor.authorMazzoni, Lucaes_ES
dc.contributor.authorForbes Hernández, Tamara Yuliett es_ES
dc.contributor.authorGasparrini, Massimilianoes_ES
dc.contributor.authorGonzález-Paramás, Ana M.es_ES
dc.contributor.authorSantos-Buelga, Celestinoes_ES
dc.contributor.authorQuiles Morales, José Luis es_ES
dc.contributor.authorBompadre, Stefanoes_ES
dc.contributor.authorMezzetti, Brunoes_ES
dc.contributor.authorBattino, Maurizioes_ES
dc.identifier.citationGiampieri, F.; et al. Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality. Molecules, 19(6): 7798-7816 (2014). [doi: 10.3390/molecules19067798]es_ES
dc.description.abstractStrawberry bioactive compounds are widely known to be powerful antioxidants. In this study, the antioxidant and anti-aging activities of a polyphenol-rich strawberry extract were evaluated using human dermal fibroblasts exposed to H2O2. Firstly, the phenol and flavonoid contents of strawberry extract were studied, as well as the antioxidant capacity. HPLC-DAD analysis was performed to determine the vitamin C and β-carotene concentration, while HPLC-DAD/ESI-MS analysis was used for anthocyanin identification. Strawberry extract presented a high antioxidant capacity, and a relevant concentration of vitamins and phenolics. Pelargonidin- and cyanidin-glycosides were the most representative anthocyanin components of the fruits. Fibroblasts incubated with strawberry extract and stressed with H2O2 showed an increase in cell viability, a smaller intracellular amount of ROS, and a reduction of membrane lipid peroxidation and DNA damage. Strawberry extract was also able to improve mitochondrial functionality, increasing the basal respiration of mitochondria and to promote a regenerative capacity of cells after exposure to pro-oxidant stimuli. These findings confirm that strawberries possess antioxidant properties and provide new insights into the beneficial role of strawberry bioactive compounds on protecting skin from oxidative stress and aging.en_EN
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.subjectLipid peroxidationes_ES
dc.subjectDNA damagees_ES
dc.titlePolyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionalityen_EN

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